The combination of nab -paclitaxel (Abraxane) and bevacizumab (Avastin) eradicates highly aggressive metastatic breast cancer in a preclinical model, Sophia Ran, PhD, reported at the SABCS (abstract 74). More>>

SAN FRANCISCO -- A personalized therapeutic vaccine breast cancer vaccine was safe and well tolerated when tested in 18 women with metastatic disease overexpressing HER-2, reported researchers here. More>>

Neuroblastoma (NB) is the most common pediatric, intra-abdominal, extracranial, solid tumor derived from nervous tissue. This malignant neoplasm occurs at an annual rate of 9.1 cases per 1 million American children younger than 15 years and is found more frequently in boys. The median age at diagnosis is 2 years for both sexes, with most cases being diagnosed by the age of 5 years. Metastatic disease is often found at presentation and represents about 70% of all newly diagnosed cases. More>>

Neovascularization has been shown to be a critical step in the progression of metastatic disease. Most tumors in humans do not grow beyond 2 to 3 mm³ without neovascularization. Angiogenesis increases tumor growth via perfusion and paracrine More>>

Persistent collapse of the right lung led to hospitalization of a 62-year-old woman with a history of colon cancer. More>>

Esophageal cancer is a rare but highly virulent malignancy in the United States, and adenocarcinoma of the esophagus has had the most rapid rate of increase of any solid tumor malignancy. Systemic metastatic disease is present in 50% of patients at diagnosis. In the remaining 50% presenting with local regional disease, systemic metastatic disease will develop in the vast majority of these patients. More>>

During an evaluation to detect metastatic disease in a 75-year-old woman with recently diagnosed cecal cancer, a CT scan of the abdomen and pelvis revealed an incidental finding of a heavily calcified gallbladder. No metastases were found. The patient had no symptoms related to gallbladder disease. More>>

INDIANAPOLIS—Adding the antiangiogenesis agent bevacizumab (Avastin) to capecitabine (Xeloda) increases the objective response rate—but not progression-free survival—in women with advanced breast cancer, according to a phase III trial. This was the first randomized trial to report results with an antiangiogenic agent in patients with metastatic disease, according to lead investigator Kathy D. Miller, MD, assistant professor of medicine in the division of hematology/oncology at Indiana University... More>>

Despite significant advances in the treatment of a variety of malignancies, highly effective therapies for most patients with metastatic renal cell carcinoma or metastatic melanoma are rare. Traditional oncologic treatment methods, such as More>>

This article will review the pertinent data on the use of chemotherapy for all stages of pancreatic cancer. For patients with metastatic disease, fluorouracil (5-FU) was the standard of care for several decades until a single More>>