Changing Treatment Landscape for Follicular Lymphoma

News
Video

This video examines the evolution in treatment and survival outcomes for patients with follicular lymphoma and highlights trials testing newer agents such as immunotherapies in this population.

In this video, Nathan H. Fowler, MD, of MD Anderson Cancer Center, discusses the evolution in treatment for patients with follicular lymphoma and the improvement in survival outcomes since the introduction of the monoclonal antibody rituximab in this setting.

Dr. Fowler also reviews the standard treatment for these patients, the role of novel antibodies following chemotherapy failure, and looks ahead at newer agents such as checkpoint inhibitors and chimeric antigen receptor (CAR) T-cell therapy currently in trials for follicular lymphoma.

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Developing odronextamab combinations following CAR T-cell therapy failure may help elicit responses in patients with diffuse large B-cell lymphoma.
Cytokine release syndrome was primarily low or intermediate in severity, with no grade 5 instances reported among those with diffuse large B-cell lymphoma.
Safety results from a phase 2 trial show that most toxicities with durvalumab treatment were manageable and low or intermediate in severity.
Investigators are currently evaluating mosunetuzumab in relapsed disease or comparing it with rituximab in treatment-naïve follicular lymphoma.
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