Michael Kim, MD, on Developing More CREB Inhibitors in Pancreatic Cancer Moving Forward

Michael Kim, MD, of The University of Texas MD Anderson Cancer Center, spoke with CancerNetwork® at the virtual American Association for Cancer Research Annual Meeting 2021 about the need for more CREB inhibitors to effectively treat patients with pancreatic cancer moving forward.

Transcription:

Work moving forward should figure out what other drugs can be combined with the CREB inhibitor we used [in our study]. There’s only one we could find, so the development of additional CREB inhibitors would be a great step forward. Also, understanding how we can mix other drugs with CREB inhibitors to shut down other collateral pathways important in KRAS signaling [will be essential]. The combination of those 2 might really lead to improved patient outcomes and a better mechanistic understanding of how mutant TP53 and KRAS can be divided and then individually conquered to fight this disease.

Reference:

Kim MP, Li X, Deng J, et al. Mutant p53 and oncogenic KRAS converge on CREB1 to drive pancreatic cancer metastasis. Presented at: AACR Annual Meeting 2021; April 10-15, 2021; virtual. Abstract 2417.