Phase III Trial of OraTest

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 15 No 2
Volume 15
Issue 2

PHOENIX-Zila, Inc. has enrolled the first patients in its phase III clinical trial of OraTest, a rinse for detecting severe dysplasia and cancer in patients at elevated risk for oral cancer. Its active ingredient is Zila Tolonium Chloride (pharmaceutical grade toluidine blue). The trial is expected to require fewer than 4,000 high-risk patients, generally requiring a single visit; it will be conducted at approximately 13 investigative sites.

PHOENIX-Zila, Inc. has enrolled the first patients in its phase III clinical trial of OraTest, a rinse for detecting severe dysplasia and cancer in patients at elevated risk for oral cancer. Its active ingredient is Zila Tolonium Chloride (pharmaceutical grade toluidine blue). The trial is expected to require fewer than 4,000 high-risk patients, generally requiring a single visit; it will be conducted at approximately 13 investigative sites.

Articles in this issue
Cancer Genome Atlas Launched With $100 Million Pilot
Immunochemical FOBT Confirms Positive Guaiac FOBT
Process of Angiogenesis Plays a Role in Response of Cancers to Radiation Therapy
TLK286 Effective, Well Tolerated in NSCLC, Early Clinical Trials Show
No Added Benefit of RT Hyperfractionation for LABC Pts
Dr. Slamon Describes Past, Present, Future of Targeted Rx
Anti-TGF-β Reduces RT-Induced Lung Injury in Animals
Desensitization Protocol Allows Chemo Administration
Gene Expression Signatures Find Best Tumor/Drug Match
Dasatinib Proves Effective in Resistant CML
Rituximab Plus GM-CSF Active in CLL Patients, Including Elderly Untreated
Phase II Trial of KRX-0401 for Refractory Myeloma Begins
Surgical Breast Biopsy Has High Reexcision Rate
Sunitinib Improves Outcomes in Imatinib-Resistant GIST
Adjuvant TC Superior to AC in Early-Stage Breast Ca

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Subscribe Now!
Recent Videos
The phase 3 NIVOSTOP trial evaluated an anti–PD-1 immunotherapy, nivolumab, in a patient population similar in the KEYNOTE-689 trial.
Opportunities to further reduce relapses include pembrolizumab-based combination therapy and evaluating the agent’s contribution before and after surgery.
For patients with locally advanced head and neck cancers, the current standard of care for curative therapy has a cure rate of less than 50%.
Treatment with toripalimab does not yield the same vascular toxicity seen with pembrolizumab in patients with advanced or metastatic nasopharyngeal carcinoma, according to Barbara Burtness, MD.
Overall survival also appears to improve with toripalimab compared with chemotherapy among patients with metastatic or advanced nasopharyngeal carcinoma.
head and neck cancer
head and neck cancer
Related Content
Data from the phase 3 KEYNOTE-689 trial support the approval of the pembrolizumab-based regimen in this locally advanced HNSCC population.

FDA Approves Perioperative Pembrolizumab Plus Radiation in HNSCC

Russ Conroy
June 12th 2025
Article

Data from the phase 3 KEYNOTE-689 trial support the approval of the pembrolizumab-based regimen in this locally advanced HNSCC population.

David Sher on the Updated ASTRO Guidelines for Oropharyngeal Cancer

David Sher on the Updated ASTRO Guidelines for Oropharyngeal Cancer

David J. Sher, MD, MPH
September 15th 2017
Podcast

In this interview we discuss new clinical guidelines from ASTRO on the use of radiotherapy in treating oropharyngeal cancer.

From breast cancer to head and neck tumors, the 2025 ASCO Annual Meeting may feature a wide range of practice-changing data across cancer care.

ASCO 2025: The Presentations That May Shift the Cancer Care Paradigm

Russ Conroy
May 23rd 2025
Article

From breast cancer to head and neck tumors, the 2025 ASCO Annual Meeting may feature a wide range of practice-changing data across cancer care.

Efti plus pembrolizumab demonstrated no new safety signals in the TACTI-003 trial.

Frontline Efti Combo Yields Meaningful Survival in PD-L1–Low HNSCC

Russ Conroy
May 8th 2025
Article

Survival data with eftilagimod alfa plus pembrolizumab compare favorably with historical results seen with standard-of-care therapies in this population.

Event-free survival events were observed in 37.5% of patients taking pembrolizumab vs 45.3% without among patients with resectable locally advanced HNSCC.

Perioperative Pembrolizumab Enhances Survival in Locally Advanced HNSCC

Ashley Chan
April 30th 2025
Article

Event-free survival events were observed in 37.5% of patients with resectable locally advanced HNSCC who took pembrolizumab vs 45.3% in those who did not.

Data from the phase 3 AK105-304 study support the approval of penpulimab in this nasopharyngeal carcinoma population.

FDA Approves Penpulimab in Non-Keratinizing Nasopharyngeal Carcinoma

Roman Fabbricatore
April 24th 2025
Article

Data from the phase 3 AK105-304 study support the approval of penpulimab in this nasopharyngeal carcinoma population.