Salma Jabbour, MD, on Next Steps for the KEYNOTE-799 Study

Video

The chief of Gastrointestinal Radiation Oncology at the Rutgers Cancer Institute of New Jersey discussed how she hopes the results of the KEYNOTE-799 study will impact testing going forward.

Updated results from the KEYNOTE-799 study, presented at the IASLC 2020 World Conference on Lung Cancer (WCLC) Singapore, revealed pembrolizumab (Keytruda) plus concurrent chemoradiation therapy may be effective for treating patients with unresectable, locally advanced, stage III non–small cell lung cancer (NSCLC).

In an interview with CancerNetwork®, Salma Jabbour, MD, chief of Gastrointestinal Radiation Oncology at the Rutgers Cancer Institute of New Jersey, explained how the results of the ongoing study may guide testing moving forward.

Transcription:

The results of this study will hopefully help to guide phase 3 testing, which is currently ongoing in KEYLYNK-012 (NCT04380636). [This study] will look at the earlier incorporation of pembrolizumab with concurrent chemo-radiotherapy and will compare it to the standard of care, which is to receive immunotherapy after the completion of chemo-radiotherapy for stage III non–small cell lung cancer. It will be very exciting to see what these results will be and how they may change or improve our practice going forward to help patients.

Recent Videos
Developing odronextamab combinations following CAR T-cell therapy failure may help elicit responses in patients with diffuse large B-cell lymphoma.
Cytokine release syndrome was primarily low or intermediate in severity, with no grade 5 instances reported among those with diffuse large B-cell lymphoma.
Safety results from a phase 2 trial show that most toxicities with durvalumab treatment were manageable and low or intermediate in severity.
Updated results from the 1b/2 ELEVATE study elucidate synergizing effects observed with elacestrant plus targeted therapies in ER+/HER2– breast cancer.
Patients with ESR1+, ER+/HER2– breast cancer resistant to chemotherapy may benefit from combination therapy with elacestrant.
Compared with second-generation tyrosine kinase inhibitors, asciminib was better tolerated in patients with chronic myeloid leukemia.
The 2 main pafolacianine components, a folate analog and a dye, are commonly used in other medical applications.
Using bispecific antibodies before or after CAR T-cell therapy in multiple myeloma is an area of education for community oncologists.
Related Content