Satya Das, MD, MSCI, on Research Presented at the 2021 ASCO Gastrointestinal Cancer Symposium

Video

The expert in hematology/oncology discussed what research he is most looking forward to seeing the results of at the meeting.

In an interview with CancerNetwork®, Satya Das, MD, MSCI, assistant professor of Medicine in the department of Medicine in the division of Hematology/Oncology at Vanderbilt University Medical Center, spoke about the research he is most excited to see presented at the 2021 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancer Symposium.

Transcription:

I’m a basically a [gastrointestinal] oncologist and I focus on neuroendocrine tumors…and also drug development. I think the things that interest me most pertain to those 2 areas. Particularly with regards to neuroendocrine tumors, I think the role for immunotherapy and the higher-grade neuroendocrine cancers is something that’s still actively being developed. There [are] some interesting data with both [peptide receptor radionuclide therapy; PRRT] outcomes in grade 3 tumors, as well as immunotherapy outcomes.

And then I think the other focus that was quite interesting to me was the overall survival results from the POLO study [NCT02184195], which is what established olaparib [Lynparza] in [patients with] BRCA-mutant [pancreatic] cancer. And actually, though [it’s] now FDA approved, the overall survival was not met between the 2 arms. I think it raises a lot of questions of how we use targeted treatment in [pancreatic] cancer.

Reference:

Golan T, Hammal P, Reni M, et al. Overall survival from the phase 3 POLO trial: Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer. J Clin Oncol. 2021;39(suppl 3):378.

Recent Videos
Developing odronextamab combinations following CAR T-cell therapy failure may help elicit responses in patients with diffuse large B-cell lymphoma.
Cytokine release syndrome was primarily low or intermediate in severity, with no grade 5 instances reported among those with diffuse large B-cell lymphoma.
Safety results from a phase 2 trial show that most toxicities with durvalumab treatment were manageable and low or intermediate in severity.
Updated results from the 1b/2 ELEVATE study elucidate synergizing effects observed with elacestrant plus targeted therapies in ER+/HER2– breast cancer.
Patients with ESR1+, ER+/HER2– breast cancer resistant to chemotherapy may benefit from combination therapy with elacestrant.
Compared with second-generation tyrosine kinase inhibitors, asciminib was better tolerated in patients with chronic myeloid leukemia.
Using bispecific antibodies before or after CAR T-cell therapy in multiple myeloma is an area of education for community oncologists.
Bulkiness of disease did not appear to impact PFS outcomes with ibrutinib plus venetoclax in the phase 2 CAPTIVATE study.
Related Content