Alan K. Burnett, MD, FRCP
Articles
Getting to the Heart of Improving Outcomes for Patients With Acute Promyelocytic Leukemia
July 15th 2012The management of patients with acute promyelocytic leukemia (APL) has been transformed over the course of the last two decades following the introduction of successful molecularly targeted therapies-all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)- which act in concert to induce degradation of the PMLRARα oncoprotein formed by the chromosomal translocation t(15;17)(q22;q21).
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