Florian Lordick, MD

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Management of Infusion Reactions in Clinical Trials and Beyond: The US and EU Perspectives

Anthony J. Cmelak, MD;Florian Lordick, MD;Markus M. Borner, MD;Richard M. Goldberg, MD;Muhammad Wasif Saif, MD
February 2nd 2009

Infusion reactions (IRs) can be broadly categorized by their immunologic mechanism. Anaphylaxis is a systemic, immediate hypersensitivity reaction mediated by factors released from interactions between immunoglobulin E (IgE) and mast cells that produce an antigen-antibody reaction.[1] Anaphylactoid reactions can be differentiated from anaphlaxis by the fact that they are not IgE-mediated but rather cytokine-mediated.

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