Phase 3 TOURMALINE-MM2 Fails to Meet Primary End Point of PFS
September 10th 2020The study is evaluating the addition of ixazomib (Ninlaro) to lenalidomide and dexamethasone versus lenalidomide and dexamethasone plus placebo in patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant.
Phase 2 CLOVER-1 Study Shows Promise for Patients with Triple Class Refractory Multiple Myeloma
September 9th 2020A clinically meaningful 40% overall response rate was seen in a subset of patients with triple class refractory multiple myeloma who received CLR 131 at a total administered dose of 60 mCi or greater.
FDA Issues Alert for Atezolizumab, Paclitaxel Combination in Patients with TNBC
September 9th 2020The agency indicated that the use of atezolizumab (Tecentriq) and paclitaxel in patients with previously untreated, inoperable, locally advanced, or metastatic triple negative breast cancer was not effective in treating the disease.
FDA Approves Pralsetinib for Treatment of Adults with Metastatic RET Fusion-Positive NSCLC
September 8th 2020The approval was based on results from the phase 1/2 ARROW clinical trial, which demonstrated efficacy for pralsetinib in patients with RET fusion-positive NSCLC with or without prior therapy, and regardless of RET fusion partner or central nervous system involvement.
The Role of Patient-Centered Medical Homes and Changes in Care Among Low-Income Patients
September 4th 2020The authors suggested that the “results of the current study have provided valuable insight into chronic medication adherence and health care use in a low-income population of patients with and without cancer.”
Study of Adherence Interventions in Children with ALL Does Not Meet Primary End Point
September 3rd 2020The study was evaluating whether a multicomponent intervention, compared with education alone, would result in a higher proportion of patients with ALL who have mercaptopurine adherence rates of 95% or higher.
Researchers Receive Grant to Initiate Study of ‘Chemo Brain’ in Pediatric Patients
September 2nd 2020This study is intended to “investigate how chemotherapy disrupts sensory processing, memory, and attention in children; where in the brain the damage is occurring; and whether there is a biomarker that can identify those who are most vulnerable.”
FDA Approves Azacitidine tablets for Continued Treatment of AML
September 1st 2020The tablets were approved for the continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or CR with incomplete blood count recovery (CRi) following intensive induction chemotherapy and who are not able to complete intensive curative therapy.