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First-Line Nivolumab Plus Relatlimab vs Nivolumab Plus Ipilimumab in Advanced Melanoma: An Indirect Treatment Comparison Using RELATIVITY-047 and CheckMate 067 Trial Data

Expert Insight on Using Dual-IO Regimens for Melanoma in Real-World Practice

Videos

Panelists discuss how nivolumab plus relatlimab may offer a similar efficacy to nivolumab plus ipilimumab in advanced melanoma, with a potentially better safety profile, based on an indirect treatment comparison using data from the RELATIVITY-047 and CheckMate 067 trials.

Panelists discuss how treatment decisions in metastatic melanoma involve balancing the benefits of immunotherapy versus targeted therapy, taking into account factors such as tumor genetics, patient response, and tolerability.

Treatment Decisions in Metastatic Melanoma: Immunotherapy vs Targeted Therapy 

Panelists discuss how the RELATIVITY-047 trial data highlights the efficacy of nivolumab plus relatlimab in managing advanced melanoma, offering improved progression-free survival with a favorable safety profile compared to with nivolumab alone.

Key Takeaways from the RELATIVITY-047 Trial: Managing Advanced Melanoma

Panelists discuss how the indirect treatment comparison of RELATIVITY-047 and CheckMate 067 suggests that nivolumab plus relatlimab may provide similar efficacy to nivolumab plus ipilimumab in advanced melanoma, with a potentially better safety profile.

Indirect Treatment Comparison: RELATIVITY-047 and CheckMate 067

Panelists discuss how dual immunotherapy for melanoma, including combinations like nivolumab plus ipilimumab or nivolumab plus relatlimab, requires careful consideration of sequencing decisions based on factors such as tumor burden, patient health status, and potential toxicity profiles.

Dual Immunotherapy IO Treatment and Sequencing Decisions for Melanoma 

Panelists discuss how treating patients with melanoma and brain metastases requires a multidisciplinary approach, emphasizing the role of immunotherapy, targeted therapy, and local treatments, while considering factors like the extent of metastasis and patient-specific factors.

Insight on Treating Patients With Melanoma With Brain Metastases

Panelists discuss how using dual immunotherapy regimens for melanoma in real-world practice involves balancing efficacy with safety, patient comorbidities, and treatment accessibility, while also addressing challenges such as immune-related adverse events and treatment sequencing.

Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

Expert Insight on Using Dual-IO Regimens for Melanoma in Real-World Practice

EP: 1.Treatment Decisions in Metastatic Melanoma: Immunotherapy vs Targeted Therapy

EP: 2.Key Takeaways from the RELATIVITY-047 Trial: Managing Advanced Melanoma

EP: 3.Indirect Treatment Comparison: RELATIVITY-047 and CheckMate 067

EP: 4.Dual Immunotherapy IO Treatment and Sequencing Decisions for Melanoma

EP: 5.Insight on Treating Patients With Melanoma With Brain Metastases

EP: 6.Expert Insight on Using Dual-IO Regimens for Melanoma in Real-World Practice