Jason Luke, MD, Discusses Advancement of Immunotherapy For Metastatic Disease at 2021 ESMO

Video

CancerNetwork® sat down with Jason Luke, MD, at the 2021 European Society for Medical Oncology Congress to talk about the latest developments in the use of immunotherapy for metastatic disease.

At the 2021 European Society of Medical Oncology Congress, CancerNetwork® spoke with Jason Luke, MD, of the University of Pittsburgh Medical Center, about advancements in immunotherapy that he’s excited about and how they may improve outcomes in patients living with metastatic disease. 

Transcript:

Across oncology, I think what’s exciting is a two-fold advancement in immunotherapy. One [area of advancement] is adjuvant clinical trials where we’re starting to apply immunotherapies to avoid metastatic disease altogether. Given the safety profile of checkpoint blockade, I’m really excited about that and that will lead to an improvement in the long term in terms of reduction in metastatic burden.

The other side of it is there’s a lot of developmental immunotherapies that are being developed. Those are new drug targets, as well as novel engineering approaches of immunotherapies. I’m really excited also about that next generation of immunotherapies that are coming along, to expand the utility of immunotherapy and reduce our reliance to chemotherapy over many lines of treatment for metastatic disease.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
Spatial transcriptomics and multiplex immunohistochemistry from samples may elucidate outcomes for patients who undergo surgical care for cancer.
Future work may focus on optimizing symptom management associated with percutaneous transesophageal gastrostomy placement in malignant bowel obstructions.
Post-operative length of stay ranged from 4 to 9 days for patients who underwent percutaneous transesophageal gastrostomy for malignant bowel obstructions.
Future research will aim to assess the efficacy of PIPAC-MMC plus systemic therapy vs systemic therapy alone in patients with peritoneal tumors.
Although small incision surgery may serve as a conduit to deliver PIPAC-MMC, it may confer benefits in the staging and treatment of peritoneal tumors.
Patients with peritoneal metastases were historically associated with limited survival and low consideration for clinical trials.
Findings from the OVARIO study show that patients with HRR–deficient and BRCA-mutated disease benefitted the most from niraparib/bevacizumab maintenance.
Select comorbidities, ECOG status, and the receipt of radiation were among the differences between a real-world cohort and the RUBY trial population.
Related Content