Marina Frimer, MD, Talks Future Treatments in Uterine Cancer

Video

Marina Frimer, MD, spoke about what the future holds for the treatment of patients with platinum-sensitive recurrent uterine cancer.

At The Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer, CancerNetwork® spoke with Marina Frimer, MD, associate chief of Research & Academic Development Central Region, and associate professor at the Donald and Barbara Zucker School of Medicine at Hofsta/Nortwell Health in New Hyde Park, New York, about recruiting patients to a trial (NCT04080284) examining maintenance niraparib (Zejula) for platinum-sensitive recurrent uterine cancer.

Transcript:

For [patients with] uterine serous cancer, we have an option for trastuzumab [Herceptin] in women who have a HER2 mutation. However, in women who don’t [harbor a mutation we don’t] have any other maintenance therapy options available at this time. For those patients, we are able to discuss the trial participation.

We really want to open this trial so that other [clinicians can send patients who] may potentially fit the criteria. Given the rarity of the tumor type, it’s very difficult to recruit patients to this trial. We’re really hoping to increase our publicity at the meeting.

Reference

Frimer M, Nizam A, Sison C, et al. Phase II trial of maintenance niraparib in patients with stage III, stage IV or platinum-sensitive recurrent uterine serous carcinoma. Presented at: 2022 SGO Annual Meeting on Women’s Cancer; March 18-21, 2022. Phoenix, Arizona.

Recent Videos
Co-hosts Kristie L. Kahl and Andrew Svonavec highlight the many advantages to attending the 42nd Annual Miami Breast Cancer Conference, with some additional tidbits to round out the main event.
Other ongoing urothelial cancer trials are assessing enfortumab vedotin–based combinations in the neoadjuvant setting.
Given resource scarcity, developing practice strategies for resource-constrained settings would require aid from commercial and government stakeholders.
Approximately 95% of those with a complete response to enfortumab vedotin plus pembrolizumab were alive after 2 years in the phase 3 EV-302 trial.
Thomas Powles, MBBS, MRCP, MD, highlighted fatigue, nausea, and peripheral neuropathy as toxicities observed with enfortumab vedotin plus pembrolizumab.
Large international meetings may facilitate conversations regarding disparities of care outside of high-income countries.
Related Content