Opinion|Videos|January 24, 2025
Overview of the CAR T-Cell Therapy Process: Apheresis, Manufacturing, Potential Bridging Therapies, Lymphodepletion, and Infusion
Panelists discuss how chimeric antigen receptor (CAR) T-cell therapy’s mechanism of action and treatment workflow requires extensive institutional coordination, from patient selection through bridging therapy and infusion, with varied approaches to managing patients during the manufacturing period across different centers.
Advertisement
Episodes in this series
Video content above is prompted by the following:
- Could you explain how CAR T-cell therapy works and describe the treatment process?
- Do you consider CAR T therapy a complex process at your institution, or have you been able to streamline the logistics and integration into clinical workflows?
- Dr Usmani to ask Dr Mailankody: Can you explain your institution’s approach to bridging therapy for patients awaiting CAR-T manufacturing and infusion?
- Do you send patients back to community center or does it happen in-house?
Advertisement
Related to this article
Pierre Gholam, MD, discussed how navigation, molecular profiling, and hub-and-spoke models can help liver tumor boards turn recommendations into care.
Neil Mehta, MD, and Laura Kulik, MD, discussed patient selection, washout timing, and posttransplant monitoring for immunotherapy before liver transplant.
Andrew Moon, MD, MPH, explained how liver function, biomarkers, and patient preferences should shape multidisciplinary treatment decisions in HCC.
Hashem B. El-Serag, MD, MPH, said HCC risk in MASLD centers on advanced fibrosis and cirrhosis, while extrahepatic cancers warrant routine screening.
More than half of patients with microsatellite-stable metastatic colorectal cancer without active liver metastases survived at least 18 months with botensilimab plus balstilimab.
Investigators will present detailed findings from a phase 2 study assessing a tambiciclib-based regimen in patients with relapsed/refractory AML at ASH 2026.
Bhanu Prasad Venkatesulu, MBBS, MD, discussed why fewer radiation oncologists perform brachytherapy, and one setting where he considers it the better option.
Chinmay Jani, MD, discusses ASCO 2026 data on lung cancer trends in younger adults and why this group has been overlooked.
Advertisement
Advertisement
Trending on CancerNetwork
1
Tambiciclib Combo Shows Activity in Relapsed/Refractory Post-Venetoclax AML
2
BOT+BAL Yields Long-Term Survival in Patients With Refractory MSS mCRC
3
Young Adults With Lung Cancer Often Fall Outside Screening Guidelines
4
MASLD Raises Liver and Other Cancer Risks, Supporting Selective HCC Surveillance
5