- ONCOLOGY Vol 12 No 1
- Volume 12
- Issue 1
Recent Advances With Chemotherapy for NSCLC: The ECOG Experience
Management of disseminated non-small-cell lung cancer has changed over the past 10 years. Newer agents, such as vinorelbine (Navelbine) and paclitaxel (Taxol), have been shown to modestly improve survival in patients with
ABSTRACT: Management of disseminated non-small-cell lung cancer has changed over the past 10 years. Newer agents, such as vinorelbine (Navelbine) and paclitaxel (Taxol), have been shown to modestly improve survival in patients with advanced disease when administered in conjunction with cisplatin (Platinol). Compared with older regimens consisting of cisplatin and a Vinca alkaloid or a podophyllotoxin, the newer regimens yield a 10- to 15-week improvement in median survival and an additional 10% to 15% in 1-year survival. Based on these results derived from randomized trials, it appears that metastatic non-small-cell lung cancer patients with good performance status should be treated with regimens containing either vinorelbine or paclitaxel in conjunction with cisplatin.[ONCOLOGY 12(Suppl 2): 67-70, 1998]
The management of non-small-cell lung cancer (NSCLC) has evolved considerably within the past decade. New drugs and drug combinations appear to provide a modest but real improvement in the survival of patients, including those with far advanced, unresectable disease. A review of earlier therapeutic results may help to establish a frame of reference from which to understand this progress.
Internal server error