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Opinion|Videos|February 16, 2024

Treatment Considerations and AE Management Strategies with HER2-Directed Therapies

Author(s)Carey K. Anders, MD, Heather Moore, CPP, PharmD, Rani Bansal, MD

Heather Moore, CPP, PharmD, presents a comprehensive summary of targeted therapies for HER2-positive breast cancer and provides expert insights into the management of adverse effects associated with these treatments.

Episodes in this series

A panel of 4 experts on breast cancer seated at a long table

EP. 1 Advancements in Treatment Strategies for HER2+ Metastatic Breast Cancer: Insights from Experts at the Duke Cancer Center

Susan Dent, MD, an expert on breast cancer

EP. 2 Approaches for 1L Therapy and Restaging in Triple-Positive mBC

A panel of 4 experts on breast cancer

EP. 3 The Role of Radiotherapy in HER2+ mBC

Susan Dent, MD, an expert on breast cancer

EP. 4 Treatment Approaches for Triple-Positive mBC in the 2L Setting and Beyond

Heather Moore, CPP, PharmD, an expert on breast cancer

EP. 5 Treatment Considerations and AE Management Strategies with HER2-Directed Therapies

Carey Anders, MD, an expert on breast cancer

EP. 6 Patient Case Presentation: A 34-Year-Old Woman with HER2+ mBC and Brain Metastases

A panel of 4 experts on breast cancer

EP. 7 HER2CLIMB: Targeting Stable and Active Brain Metastases in Advanced HER2+ Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 8 BRIDGET: Preventing Secondary Brain Metastases in Advanced HER2+ Breast Cancer

Heather Moore, CPP, PharmD, an expert on breast cancer

EP. 9 Strategies for AE Management with Tucatinib in Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 10 D-TORCH: Topical Diclofenac for Reducing Hand Foot Syndrome with Capecitabine

Rani Bansal, MD, an expert on breast cancer

EP. 11 Patient Case Presentation: A 34-Year-Old Woman with HER+ mBC and Brain Metastases

A panel of 4 experts on breast cancer seated at a long table

EP. 12 Advancements in Treating Brain Metastases in HER2+ Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 13 Radiation Necrosis with ADCs and Concurrent Radiotherapy for Brain Metastases

A panel of 4 experts on breast cancer seated at a long table

EP. 14 Strategies for AE Management with T-DXd in Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 15 Looking Ahead: Future Perspectives and Unmet Need in HER+ Breast Cancer

Carey K. Anders, MD, an expert on breast cancer

EP. 16 Recent Data from KATHERINE and APHINITY in HER2+ Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 17 Updates from HER2CLIMB in HER2+ Metastatic Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 18 BRIDGET Study: Tucatinib Plus HER2-Directed Antibody Therapy in Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 19 Future Perspectives on HER2+ Breast Cancer Treatment

EP. 20 Applying Updated Findings From SABCS 2023 to HER2+ Breast Cancer Practice

EP. 20 Applying Updated Findings From SABCS 2023 to HER2+ Breast Cancer Practice

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Rebecca Heist, MD, MPH; Alex A. Adjei, MD, PhD, FACP; Sandip Patel, MD, FASCO; Jeremy Segal, MD, PhD

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Rami Komrokji, MD; Gabriela Hobbs, MD; John Mascarenhas, MD; Naveen Pemmaraju, MD

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Balazs Halmos, MD, MS; Enriqueta Felip, MD, PhD; Julia Rotow, MD

$Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma$

Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Vinay K. Puduvalli, MD; Manmeet Ahluwalia, MD, MBA; Stephen J. Bagley, MD, MSCE; Angela Waanders, MD, MPH, MS

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Gail J. Roboz, MD; Hagop Kantarjian, MD; Catherine Lai, MD, MPH; Amer Zeidan, MBBS, MHS

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

Jonathan W. Goldman, MD; Percy Lee, MD, FASTRO; Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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