Treatment Options for Transplant-Ineligible Multiple Myeloma
Nina Shah, MD, discusses the current treatment options for treating patients with transplant-ineligible multiple myeloma.
Nina Shah, MD: For transplant-ineligible patients, we traditionally had been using things like bortezomib [Velcade], lenalidomide [Revlimid], and dexamethasone, or VRd light, with lenalidomide maintenance therapy and that’s a perfectly good combination to use. The most recent MAIA trial [NCT02252172] data that were presented at the European [Hematology Association] Congress really did solidify the role for daratumumab [Darzalex], lenalidomide, dexamethasone in patients who are transplant-ineligible because there’s both a PFS [progression-free survival] and an overall survival advantage. It sounds like there’s going to be some nice quality-of-life data to suggest that these people are doing better despite being on therapy for longer.
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![“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fcancernetwork%2F267879fc15a40ec8d3ed04d8ee9c1f044b49ee89-2990x1692.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 "“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.")
