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Opinion|Videos|November 21, 2023

Tucatinib in Patients With CRC: Data From MOUNTAINEER-01

Author(s)Tanios S. Bekaii-Saab, MD, FACP, Daniel H. Ahn, DO, Christina S. Wu, MB, BCh, MD

In the Phase 2 MOUNTAINEER-01 study of patients with HER2-positive metastatic colorectal cancer who were chemo-refractory, the combination of tucatinib and trastuzumab showed an impressive response rate and disease control rate, and median duration of response up to 12 months; Dr. Ahn notes these results compare favorably to prior studies of dual HER2 inhibition, with MOUNTAINEER-01 showing higher response rates.

Episodes in this series

Expert panel smiling at camera.

EP. 1 Overview of Colorectal Cancer (CRC)

Expert panel smiling at camera.

EP. 2 Current Treatment Options for CRC

Expert panel smiling at camera.

EP. 3 The Role of Biomarker and Molecular Testing in CRC

Expert panel smiling at camera.

EP. 4 The Role of HER2 in CRC

New treatment updates could help find more patient subtypes to target and treat in the world of CRC.

EP. 5 Multidisciplinary Care and New Treatment Options in CRC

EP. 6 Case Presentation: A 50-Year-Old Man With Metastatic CRC (mCRC)

EP. 6 Case Presentation: A 50-Year-Old Man With Metastatic CRC (mCRC)

EP. 7 Tucatinib in Patients With CRC: Data From MOUNTAINEER-01

EP. 7 Tucatinib in Patients With CRC: Data From MOUNTAINEER-01

EP. 8 Strategies for Adverse Event Management in Patients With CRC Receiving Tucatinib

EP. 8 Strategies for Adverse Event Management in Patients With CRC Receiving Tucatinib

EP. 9 MOUNAINEER-03: Tucatinib in Combination with Trastuzumab and Chemotherapy in Patients With HER2+ CRC

EP. 9 MOUNAINEER-03: Tucatinib in Combination with Trastuzumab and Chemotherapy in Patients With HER2+ CRC

EP. 10 Case Presentation: A 64-Year-Old Woman With HER2+ mCRC

EP. 10 Case Presentation: A 64-Year-Old Woman With HER2+ mCRC

EP. 11 Trastuzumab Deruxtecan in Patients with HER2+ mCRC: The DESTINY-CRC01 Trial

EP. 11 Trastuzumab Deruxtecan in Patients with HER2+ mCRC: The DESTINY-CRC01 Trial

EP. 12 Managing Interstitial Lung Disease in Patients With HER2+ mCRC Receiving Trastuzumab Deruxtecan

EP. 12 Managing Interstitial Lung Disease in Patients With HER2+ mCRC Receiving Trastuzumab Deruxtecan

EP. 13 Clinician Insights on the Treatment of Patients With CRC

EP. 13 Clinician Insights on the Treatment of Patients With CRC

EP. 14 Future Perspectives and Unmet Needs in HER2+ mCRC Treatment

EP. 14 Future Perspectives and Unmet Needs in HER2+ mCRC Treatment

EP. 15 Key Takeaways for Community Oncologists Treating Patients With HER2+ mCRC

EP. 15 Key Takeaways for Community Oncologists Treating Patients With HER2+ mCRC

EP. 16 A Variety of Treatment Options Are Becoming Available in CRC

EP. 16 A Variety of Treatment Options Are Becoming Available in CRC

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Enhancing Prostate Cancer Outcomes – The Role of PSMA and Targeted Treatment Strategies

Enhancing Prostate Cancer Outcomes – The Role of PSMA and Targeted Treatment Strategies

Ana Kiess, MD, PhD; Erin Grady, MD, CCD, FACNM, FSNMMI; Himanshu Nagar, MD, MS; Scott T. Tagawa, MD, MS, FASCO, FACP

(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

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