Osimertinib/Chemotherapy Attains Japanese Approval in EGFR+ Advanced NSCLC
The approval for osimertinib/chemotherapy by the Japanese Pharmaceuticals and Medical Device Agency was based on results from the phase 3 FLAURA2 trial.
Addressing Challenges in TP53-Mutant Acute Myeloid Leukemia
Future meetings may address how immunotherapy, bispecific agents, and CAR T-cell therapies can further impact the AML treatment paradigm.
Mitazalimab/Chemo Prolongs Survival, Responses in Pancreatic Cancer
More than half of the patients who received mitazalimab plus chemotherapy experienced an unconfirmed objective response in the phase 2 OPTIMIZE-1 study.
Menin Inhibitor Developments Move Acute Myeloid Leukemia Landscape Forward
Treatment with revumenib appeared to demonstrate efficacy among patients with KMT2A-rearranged acute leukemia in the phase 2 AUGMENT-101 study.
Durvalumab Shows Improvement in EFS/OS for Muscle-Invasive Bladder Cancer
Durvalumab improved efficacy in patients with muscle-invasive bladder cancer.
American Society for Radiation Oncology Names Vivek S. Kavadi as CEO
Vikek S. Kavadi, MD, MBA, FASTRO, succeeds Laura Thevenot, who plans to retire at the end of 2024 after leading the organization since 2002.
FDA Places Partial Holds on 3 Trials for Solid Tumor Treatment, Azenosertib
Two deaths due to presumed sepsis in patients treated in the DENALI trial led to the clinical holds on the advanced solid tumor treatment.
35 Impact of Comorbidities on Real-World (rw) Clinical Outcomes of Patients (pts) With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2–Negative (HR+/HER2–) Advanced Breast Cancer (ABC) Treated With Palbociclib (PAL) and Enrolled in POLARIS
Perioperative Modified FOLFIRINOX Shows Encouraging Outcomes in Pancreatic Cancer
Longer survival rates were experienced by patients receiving chemotherapy both before and after surgery vs only after surgery.
Momelotinib Receives Japanese Approval for Treatment of Myelofibrosis
Approved for use in newly diagnosed and previously treated myelofibrosis, momelotinib may addresses key manifestations of the disease.
European Commission Approves Fruquintinib in Pretreated Metastatic CRC
Data from FRESCO-2 support the approval of fruquintinib for those with previously treated metastatic colorectal cancer in the European Union.
Advocate Outlines Resources for Chronic Myeloid Leukemia Population
Advocacy groups such as Cancer Support Community and the Leukemia & Lymphoma Society may help support patients with CML undergoing treatment.
Ensuring Quality Outcomes in Hematologic Cancer Subgroups at EHA 2024
Experts discuss updated findings presented at the 2024 EHA Congress in diseases such as mantle cell lymphoma and acute myeloid leukemia.
Assessing the Future With “Promising” Antibody Drug Conjugates in Breast Cancer
Paolo Tarantino, MD, discusses the potential utility of agents such as datopotamab deruxtecan and enfortumab vedotin in patients with breast cancer.
36 MONARCH 3: Final Overall Survival Results of Abemaciclib Plus a Nonsteroidal Aromatase Inhibitor as First-Line Therapy for HR+/HER2– Advanced Breast Cancer
Mitigating ILD Following T-DXd in HR+, HER2-Low Metastatic Breast Cancer
Paolo Tarantino, MD, highlights strategies related to screening and multidisciplinary collaboration for managing ILD in patients who receive T-DXd.
37 Estimating the Direct and Indirect Resource Burden of Treatment Management With Current Standard of Care or Elacestrant for ER+, HER2–, ESR1-Mutated Advanced or Metastatic Breast Cancer Patients: A Population- Level Provider Model
ASTRO Updates Guidelines for Radiation Therapy in HPV-Associated OPSCC
As the practice of radiation therapy evolves in HPV-associated OPSCC, updated evidence-based ASTRO guidelines may help inform clinical practices.
FDA Approves Adagrasib/Cetuximab in KRAS G12C-Mutated CRC
Data from the colorectal cancer cohort of the KRYSTAL-1 trial support the accelerated approval of adagrasib/cetuximab in KRAS G12C–mutated disease.
Early Access to EMRs May Improve the Patient Experience in Oncology
Joleen Hubbard, MD, explains why allowing access to results can improve patient’s outlook on treatments and understanding of their disease.
EMA Validates Application for Subcutaneous Nivolumab in Solid Tumors
The European Medicines Agency will begin a centralized review process for subcutaneous nivolumab across multiple solid tumor indications.
Golidocitinib Receives Chinese Approval in Relapsed/Refractory PTCL
Golidocitinib monotherapy had a superior clinical benefit in patients with relapsed/refractory peripheral T-cell lymphoma vs existing treatments.
AI-Assisted Contours Exhibit High Accuracy in Evaluating Prostate Cancer
Compared with cognitively-defined and hemigland contours, AI-assisted cancer contours delivered a greater balanced accuracy rate.
Capivasertib Combo Earns European Approval in ER+/HER2– Breast Cancer
Data from CAPItello-291 support the approval of capivasertib/fulvestrant for ER-positive, HER2-negative breast cancer in the European Union.
Cryoablation Approach Linked to Shorter Hospitalizations, High Recurrence-Free Rate for Kidney Cancer
A minimally invasive cryoablation technology system designed to treat patients with kidney tumors and elicit an 89.65% recurrence-free rate.
Robotic Hepatectomy May Demonstrate Safety in Liver Cancer
Findings from a retrospective study showed that outpatient robotic hepatectomies resulted in no mortalities across 307 procedures.
Expert Highlights Risk Factors for Disease Progression in Polycythemia Vera
Data from the REVEAL study affirm elevated white blood cell counts and higher variant allele frequency as risk factors for progression in polycythemia vera.
Sonrotoclax Combo Shows Enduring Responses in Relapsed/Refractory CLL/SLL
Phase 1 data show no dose-limiting toxicities with sonrotoclax plus zanubrutinib for patients with relapsed/refractory CLL or SLL.
No Ruxolitinib Benefit Reduction Noted After Myelofibrosis-Related Anemia
Data from the phase 3b JUMP trial support the use of ruxolitinib in myelofibrosis regardless of baseline or treatment-related anemia.
Capivasertib Combo Does Not Meet OS End Points in Advanced TNBC
Capivasertib's safety profile in the CAPItello-290 trial was comparable with prior reports of the agent in advanced triple-negative breast cancer.