SAN FRANCISCO-A regimen combining the monoclonal antibody rituximab (Rituxan) with fludarabine (Fludara) and cyclophosphamide may become the standard treatment for patients with chronic lymphocytic leukemia (CLL). That projection is based on preliminary findings from a phase II trial of 56 previously untreated patients with advanced CLL presented at the American Society of Hematology annual meeting.
NEW YORK-Long banished from the pharmacopoeia because of its teratogenic effects, thalidomide (Thalomid) has recently reemerged as a potentially promising chemotherapeutic agent in a variety of cancers. Four presentations at the Chemotherapy Foundation Symposium XVIII looked at its use as a single agent and in combination therapy.
BOSTON-A new regimen of adjuvant radiation therapy and chemotherapy significantly raised 3-year survival rates for locally advanced stomach cancer patients in a randomized phase III intergroup trial reported at the annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO).
BETHESDA, Md-The National Cancer Institute has requested $5.03 billion in its "bypass budget" for fiscal year 2002, which begins Oct. 1, 2001. The request represents an increase of $1.525 billion over the $3.5 billion President Clinton asked Congress to provide the Institute for FY 2001, and $1.27 billion above the actual FY 2001 appropriation granted by Congress ($3.76 billion).
BOSTON-A new, intensity modulated radiation therapy delivery system allows patients to lie down rather than stand up for total body irradiation (TBI) and avoid the discomfort of heavy lead shields to block the lungs, John T. Keane, PhD, reported at the American Society for Therapeutic Radiology and Oncology (ASTRO) annual meeting.
BOSTON-Combining standard radiation with a new drug called motexafin gadolinium (Xcytrin) produced substantial benefits for cancer patients with brain metastases in the lead-in phase of an ongoing phase III clinical trial, according to a report presented at the American Society for Therapeutic Radiology and Oncology (ASTRO) annual meeting.
WASHINGTON-Since its inception 5 years ago, the Campaign for Tobacco-Free Kids has become a major force in the policy wars over tobacco. Media savvy and quick to respond to news opportunities, the Campaign has been effective in publicizing the deceptive practices of the tobacco industry, its political contributions at the state and national level, and its changing advertising practices aimed at enticing youngsters into smoking.
BETHESDA, Md-The National Cancer Institute has reported results of a study investigating the possible link between brain cancer and cell phone use weeks ahead of its scheduled publication in the New England Journal of Medicine.
Approaches to cancer treatment have rapidly grown complex and costly, causing heightened awareness among patients, physicians, employers, and insurance providers. Annual costs for cancer are about $107 billion, accounting for 20% of all health care costs.[1]
The optimal management of opioid-related side effects is hampered by a lack of comparative studies of management strategies. The prevalence of such side effects is influenced by the extent of disease, the patient’s
The optimal management of opioid-related side effects is hampered by a lack of comparative studies of management strategies. The prevalence of such side effects is influenced by the extent of disease, the patient’s
The optimal management of opioid-related side effects is hampered by a lack of comparative studies of management strategies. The prevalence of such side effects is influenced by the extent of disease, the patient’s
Docetaxel (Taxotere), gemcitabine (Gemzar), and irinotecan (Camptosar, CPT-11) are active single agents in a variety of solid tumors. In combination, synergism may be schedule dependent. Preclinical studies suggested
Irinotecan (Camptosar) is an active chemotherapeutic agent for lung, gastric, esophageal, and colorectal cancers and a potent radiosensitizer. This phase I study was designed to assess the maximum tolerated dose of weekly
The use of thalidomide (Thalomid) in the treatment of hematologic diseases and in solid tumors as monotherapy or in combination with other agents is an exciting development in cancer therapy. Researchers actively involved in studying the role of thalidomide in cancer treatment were convened at a special investigators’ meeting held this past May in New Orleans. The articles in this supplement are based on the presentations made at this investigators’ meeting.
Recent evidence suggests that angiogenesis is increased in multiple myeloma and has prognostic value in the disease. Based on the increased angiogenesis observed in myeloma, thalidomide (Thalomid) has been studied as
I am writing in reference to your “Oncology Rounds” section in the September 2000 issue of Oncology News International (page 18). In the first case, entitled “What further therapy for this woman postmastectomy?” I noted that in the answer given by I. Craig Henderson, MD, there was no specific mention of adjuvant radiation therapy.
CALLAHAN, Australia-A new study suggests that the Faces Pain Scale (FPS) is “sensitive and discriminating” for use in evaluating pain in young children, but does not function as a truly linear scale. Children in the study had difficulty discriminating among Faces 3, 4, and 5 and between Faces 5 and 6, said Mark Hunter, PhD, of the Department of Psychology, University of Newcastle.
BETHESDA, Md-Two new research centers funded by the National Institutes of Health will focus on basic and clinical research of complementary and alternative medicine (CAM) cancer therapies. The centers, at Johns Hopkins University and the University of Pennsylvania, will each receive nearly $8 million over 5 years.
NEW YORK-About 85% of cancer patients in a national survey said they were unsure or unaware of their possible eligibility to be in clinical trials, and 75% said they would have tried to enroll had they known.
BOSTON-A new electrosurgical tool that seals blood vessels without staples or vascular clips is safe and effective for laparoscopic colon surgery, according to a study reported at the American Society of Colon and Rectal Surgeons (ASCRS) annual meeting.
RESEARCH TRIANGLE PARK, NC-Trizivir, Glaxo-Wellcome’s new triple-drug anti-HIV combination, has received FDA approval. The agent is given as one tablet twice daily, with no food or water restrictions.
HOUSTON-Supportive care for patients undergoing allogeneic hematopoietic stem cell transplantation presents a series of challenges, from regimen-related toxicity to chronic graft-versus-host disease (GVHD), said Daniel Couriel, MD, assistant professor of blood and marrow transplantation, M.D. Anderson Cancer Center.
WASHINGTON-Several health groups have demanded that R.J. Reynolds Co. withdraw its new Eclipse cigarette from test marketing after an analysis showed that the cigarette exposes smokers to greater amounts of carcinogens than two currently available “ultralight” brands. The company has said that Eclipse contains fewer carcinogens than other cigarettes and may reduce the risk of smoking-related cancers.
BOSTON-Patients diagnosed with orbital lymphoma should have a complete staging workup before radiation therapy, according to a Rare Cancer Network presentation at the American Society for Therapeutic Radiology and Oncology (ASTRO) annual meeting.
WASHINGTON-“Without even waiting for the research of tomorrow, we could save tens or hundreds of thousand of lives if we could apply 100% of what we know now about breast cancer diagnosis and treatment,” said Gabriel Hortobagyi, MD, chairman of Breast Medical Oncology, M.D. Anderson Cancer Center. “There is still a persistent gap between what we have learned and its application into clinical practice, simply because the translation of research into clinical practice is very slow.”
BETHESDA, Md-The National Cancer Institute (NCI) has launched its new antismoking initiative, Research in State and Community Tobacco Control Interventions, by awarding 12 grants totaling $13 million. The money will support the first year of 4-year research projects on local, state, and multistate tobacco prevention and control programs.
The book Progress in Anti-Cancer Chemotherapy, Volume II is the second of a series of three books edited by Drs. Hortobagyi and Khayat, and published by different publishing houses between 1998 and 1999. Volume II is a collection of
PHILADELPHIA-The Society for Nutritional Oncology Adjuvant Therapy (NOAT) is an interdisciplinary professional organization that addresses the role of nutrition and metabolism in oncology. Founded in 1994, NOAT is the first organization devoted solely to studying the role of nutrition in cancer (see box).
CHICAGO-The diagnosis of ductal carcinoma in situ (DCIS) usually is straightforward from a pathologic point of view. However, microinvasion and histologically ambiguous lobular carcinoma in situ (LCIS) lesions may be difficult to distinguish from DCIS, Stuart Schnitt, MD, said at the Second Annual Lynn Sage Breast Cancer Symposium, sponsored by Northwestern University Medical School.