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MIAMI, Florida-Two separate multicenter trials suggest that dose titration in patients with chronic, moderate to severe pain can be achieved as readily with controlled-release (CR) oral oxyco-done (OxyContin) given once every 12 hours as with an oral intermediate-release (IR) formulation given four times a day.

NEW YORK-Preliminary findings from a study of long-term cancer survivors suggest a linkage of cognitive deficits to standard-dose chemotherapy, Timothy Ahles, PhD, reported at the Pan American Congress of Psychosocial and Behavioral Oncology.

A relatively simple technique, pioneered by a North Carolina physician, can distinguish between patients who can metabolize docetaxel (Taxotere) normally and those who need to receive lower doses for safety, according to a recent study. Researchers

Pentostatin (Nipent) is a nucleoside analog that inhibits the activity of the enzyme adenosine deaminase. Inhibition of adenosine deaminase blocks the deamination of adenosine to inosine and deoxyadenosine to deoxyinosine in the purine

A new book, Me and My Marrow: A Kid’s Guide to Bone Marrow Transplants, helps guide children with cancer through the transplant procedure. The book was inspired by 13-year-old Christina Cuzzone, of Northbrook, Illinois, who was diagnosed with leukemia at age 9 and underwent a BMT. After recovering from the transplant, Christina recognized the need for a book to help other children.

WASHINGTON-Scientific studies provide insufficient evidence that consuming high doses of antioxidants in the diet and as supplements can prevent chronic diseases, according to a new report by the Institute of Medicine (IOM), a part of the National Academy of Sci-ences. Indeed, megadoses of some antioxidants may lead to ill health rather than benefits, the report warned.

NEW ORLEANS-Positive/negative purging of peripheral blood stem cell (PBSC) grafts allows preparation of highly purified CD34+ fractions and up to 6 log of tumor cell depletion in patients with chronic lymphocytic leukemia (CLL), according to a study conducted at the University of Kiel, Germany. Peter Dreger, MD, reported the results at the 41st annual meeting of the American Society of Hematology (ASH).

The perception is that it is normally Democrats who support price controls; that is why Sen. Slade Gorton (R-WA), who

ASCO-The American Society of Clinical Oncology (ASCO) has embarked upon “one of the most important and far reaching initiatives ever undertaken by any medical specialty society-the National Initiative on Cancer Care Quality (NICCQ),” Joseph S. Bailes, MD, outgoing ASCO president, said at the Society’s 36th annual meeting held in New Orleans.

NEW ORLEANS-A nonmagnetic method of depleting B cells during purging before autologous peripheral blood stem cell (PBSC) transplantation greatly decreases the nonspecific cell loss that can occur when cells cross a magnet, as in other techniques. The nonmagnetic method is also simple and quick, John Gribben, MD, of Dana-Farber Cancer Institute, said at the 41st annual meeting of the American Society of Hematology.

Accurate imaging of the hepatic and extrahepatic abdomen is an important component of the management of many patients with cancer. Historically, clinicians have relied on computed tomography (CT). The use of intravenous (IV) and oral contrast

FT. LAUDERDALE, Fla-Palliative care, broadly defined, can benefit cancer patients who are newly diagnosed and who are in active treatment, as well as those who are near death. In creating guidelines for palliative care, the National Comprehensive Cancer Network (NCCN) Palliative Care Panel members found agreement on this point.

WASHINGTON-As part of its move to self-management, the American Society of Hematology (ASH) has moved its offices to a new independent location in Washington, DC. Formerly with an association management firm, the ASH executive committee voted in 1999 for the Society to make the move. Martha Liggett, Esq, will continue to serve as executive director.

SAN DIEGO-AIDS experts have long worried that human immunodeficiency virus (HIV) infection might increase a woman’s risk of cervical cancer, particularly in the presence of concurrent human papillomavirus (HPV) infection.

FT. LAUDERDALE, Fla-Older cancer patients are at increased risk for complications of chemotherapy, and such risks must be weighed against the potential benefits of treatment. However, chronologic age is an imprecise gauge of physical condition. A geriatric assessment can help the physician determine the best approach to cancer treatment, Lodovico Balducci, MD, said at the fifth annual conference of the National Comprehensive Cancer Network (NCCN).

ROCKVILLE, Md-The FDA has proposed rules that would enable it to authorize states to certify, inspect, and enforce quality standards at mammography facilities within their boarders. The rules would implement a provision of the Mammography Quality Standards Act of 1992 (MQSA) and significantly increase the role of the states in the process.

Medicare has made some changes in how it will calculate payments to outpatient cancer clinics when the new

SUNNYVALE, California-RadioTherapeutics Corporation has received clearance from the FDA to market its RF System for the ablation of nonresectable liver lesions. The system, consisting of the RF 2000 Radio-frequency Generator and family of LeVeen Needle Electrodes, provides radiofrequency (RF) energy to heat and destroy soft tissue.

WASHINGTON-When the National Coalition of Cancer Research (NCCR) brought its concerns about the impact of proposed patient privacy regulations on medical research to Capitol Hill, it got strong confirmation about its fears from the founder of the House Cancer Awareness Working Group.

ORLANDO-The technology for mammography to go digital is here, but it may take 5 or 10 years for the transition because of the higher costs that the newer method entails, Maria Kallergi, PhD, said at the Joint Cancer Conference of the Florida Universities.

CLEVELAND-Distance education for continuing medical education (CME), often conducted via e-mail and the Inter-net, is designed for independent study at the participant’s convenience. It also eliminates the need for travel, an important consideration in a country like Canada with a large geographic area and a small population.

WASHINGTON-A safer cigarette from R.J. Reynolds Tobacco Company? Leading antismoking groups don’t buy it, and Health and Human Services Secretary Donna E. Shalala expressed “significant concerns about the marketing plans” for RJR’s new Eclipse brand.

SAN DIEGO-Human immunodeficiency virus (HIV)-infected women from the southeastern United States are more likely to have contracted HIV through heterosexual contact, to be black, and to harbor multiple subtypes of human papillomavirus (HPV) than are HIV-positive women from other parts of the country, Ronald D. Alvarez, MD, said at the 31st Annual Meeting of the Society of Gynecologic Oncologists (SGO).

NEW ORLEANS-A mutant her-pesvirus has been shown, in vitro and in vivo, to be highly oncolytic against colon carcinoma cells in liver metastases. On-colysis induced by the replication of this virus, combined with cyclophosphamide prodrug activation, appears to hold therapeutic promise in this setting, according to research presented at the Society of Surgical Oncology Cancer Symposium.

CHICAGO-While the main objective in caring for cancer patients has been to prolong life and to focus on short-term and long-term survival, more recent efforts include considerations of health-related quality of life (QOL).[1,2] The World Health Organization defines QOL as “not merely the absence of disease but a state of physical, emotional, and social well being.”[3]

In his excellent review, Dr. Mitsuyasu correctly highlights the three most important ingredients that play a role in the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related Kaposi’s sarcoma (KS)-Kaposi’s sarcoma herpesvirus/human herpesvirus type 8 (KSHV/HHV-8); altered expression and response to cytokines; and stimulation of KS growth by the human immunodeficiency virus (HIV)-1 trans-activating protein, Tat. Recent studies have provided tremendous insight into the process whereby KSHV/HHV-8 creates the inflammatory-angiogenic state that characterizes KS.

Heidelberger and associates[1] synthesized fluorouracil (5-FU) in 1957 after observing that rat hepatomas utilized radiolabeled uracil more avidly than malignant tissues. For the past 40 years, 5-FU has been extensively investigated in various schedules, in combination with biochemical modulators, and for a variety of malignancies.[2]

Dr. Mitsuyasu has been doing clinical research in patients with AIDS-related Kaposi’s sarcoma (KS) since the beginning of the AIDS epidemic, and his review reflects this breadth of experience. It provides a well-rounded and up-to-date assessment of the pathophysiology, evaluation, and treatment of AIDS-related KS that should be a useful guide for practicing physicians.

In his article, Dr. Mitsuyasu concisely reviews a large body of data concerning the etiology, pathogenesis, epidemiology, and treatment of Kaposi’s sarcoma (KS) in the setting of the human immunodeficiency virus (HIV) infection. As he correctly points out, effective highly active antiretroviral therapy (HAART), with its consequent improvements in immune function and decrease in production of viral and cytokine cofactors that promote KS growth, has been partly responsible for the decline of KS incidence in areas with ready access to HIV therapy.

Managing the infectious complications associated with pentostatin (Nipent), used alone or in combination with other agents in patients with low-grade lymphomas, poses a significant problem for clinicians. Since there is limited