EU’s CHMP Recommends Epcoritamab Approval in R/R Follicular Lymphoma
The European Commission is expected to decide on approving epcoritamab in relapsed/refractory follicular lymphoma later in 2024.
Nivolumab Combo Improves HRQOL Vs Chemo in MSI-H/dMMR Metastatic CRC
HRQOL data from the CheckMate 8HW trial may further support frontline nivolumab/ipilimumab for those with MSI-H or dMMR metastatic colorectal cancer.
FDA Approves Novel Formulation for Breast and Ovarian Cancers
A ready-to-dilute formula of SH-105 has been approved by the FDA to treat breast and ovarian cancers.
Acalabrutnib Combo Shows PFS Benefit in Elderly MCL Population
Frontline acalabrutinib plus bendamustine/rituximab may become a new standard therapy in MCL, according to Michael Wang, MD.
CAR T-Cell Therapy Demonstrates Promising Results for mCRPC
In a phase 1 trial, City of Hope’s CAR T-cell therapy showed minimal adverse effects and promising therapeutic activity for advanced prostate cancer.
FDA Sends CRL for Patritumab Deruxtecan in Advanced EGFR+ NSCLC
The complete response letter for patritumab deruxtecan is based on findings related to a third-party manufacturing site inspection.
Younger Age Improves Pregnancy Prospects After ET Therapy Pause in HR+ Breast Cancer
Updated results from the POSITIVE trial found that patients younger than 35 years had a higher likelihood of achieving pregnancy during an endocrine therapy pause for HR-positive breast cancer.
FDA Grants Accelerated Approval to Epcoritamab in R/R Follicular Lymphoma
Findings from the EPCORE NHL-1 trial support the FDA approval of epcoritamab in relapsed/refractory follicular lymphoma.
Osimertinib/Chemotherapy Attains Japanese Approval in EGFR+ Advanced NSCLC
The approval for osimertinib/chemotherapy by the Japanese Pharmaceuticals and Medical Device Agency was based on results from the phase 3 FLAURA2 trial.
Addressing Challenges in TP53-Mutant Acute Myeloid Leukemia
Future meetings may address how immunotherapy, bispecific agents, and CAR T-cell therapies can further impact the AML treatment paradigm.
Mitazalimab/Chemo Prolongs Survival, Responses in Pancreatic Cancer
More than half of the patients who received mitazalimab plus chemotherapy experienced an unconfirmed objective response in the phase 2 OPTIMIZE-1 study.
Menin Inhibitor Developments Move Acute Myeloid Leukemia Landscape Forward
Treatment with revumenib appeared to demonstrate efficacy among patients with KMT2A-rearranged acute leukemia in the phase 2 AUGMENT-101 study.
Durvalumab Shows Improvement in EFS/OS for Muscle-Invasive Bladder Cancer
Durvalumab improved efficacy in patients with muscle-invasive bladder cancer.
American Society for Radiation Oncology Names Vivek S. Kavadi as CEO
Vikek S. Kavadi, MD, MBA, FASTRO, succeeds Laura Thevenot, who plans to retire at the end of 2024 after leading the organization since 2002.
FDA Places Partial Holds on 3 Trials for Solid Tumor Treatment, Azenosertib
Two deaths due to presumed sepsis in patients treated in the DENALI trial led to the clinical holds on the advanced solid tumor treatment.
35 Impact of Comorbidities on Real-World (rw) Clinical Outcomes of Patients (pts) With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2–Negative (HR+/HER2–) Advanced Breast Cancer (ABC) Treated With Palbociclib (PAL) and Enrolled in POLARIS
Perioperative Modified FOLFIRINOX Shows Encouraging Outcomes in Pancreatic Cancer
Longer survival rates were experienced by patients receiving chemotherapy both before and after surgery vs only after surgery.
Momelotinib Receives Japanese Approval for Treatment of Myelofibrosis
Approved for use in newly diagnosed and previously treated myelofibrosis, momelotinib may addresses key manifestations of the disease.
European Commission Approves Fruquintinib in Pretreated Metastatic CRC
Data from FRESCO-2 support the approval of fruquintinib for those with previously treated metastatic colorectal cancer in the European Union.
Advocate Outlines Resources for Chronic Myeloid Leukemia Population
Advocacy groups such as Cancer Support Community and the Leukemia & Lymphoma Society may help support patients with CML undergoing treatment.
Ensuring Quality Outcomes in Hematologic Cancer Subgroups at EHA 2024
Experts discuss updated findings presented at the 2024 EHA Congress in diseases such as mantle cell lymphoma and acute myeloid leukemia.
Assessing the Future With “Promising” Antibody Drug Conjugates in Breast Cancer
Paolo Tarantino, MD, discusses the potential utility of agents such as datopotamab deruxtecan and enfortumab vedotin in patients with breast cancer.
36 MONARCH 3: Final Overall Survival Results of Abemaciclib Plus a Nonsteroidal Aromatase Inhibitor as First-Line Therapy for HR+/HER2– Advanced Breast Cancer
Mitigating ILD Following T-DXd in HR+, HER2-Low Metastatic Breast Cancer
Paolo Tarantino, MD, highlights strategies related to screening and multidisciplinary collaboration for managing ILD in patients who receive T-DXd.
37 Estimating the Direct and Indirect Resource Burden of Treatment Management With Current Standard of Care or Elacestrant for ER+, HER2–, ESR1-Mutated Advanced or Metastatic Breast Cancer Patients: A Population- Level Provider Model
ASTRO Updates Guidelines for Radiation Therapy in HPV-Associated OPSCC
As the practice of radiation therapy evolves in HPV-associated OPSCC, updated evidence-based ASTRO guidelines may help inform clinical practices.
FDA Approves Adagrasib/Cetuximab in KRAS G12C-Mutated CRC
Data from the colorectal cancer cohort of the KRYSTAL-1 trial support the accelerated approval of adagrasib/cetuximab in KRAS G12C–mutated disease.
Early Access to EMRs May Improve the Patient Experience in Oncology
Joleen Hubbard, MD, explains why allowing access to results can improve patient’s outlook on treatments and understanding of their disease.
EMA Validates Application for Subcutaneous Nivolumab in Solid Tumors
The European Medicines Agency will begin a centralized review process for subcutaneous nivolumab across multiple solid tumor indications.
Golidocitinib Receives Chinese Approval in Relapsed/Refractory PTCL
Golidocitinib monotherapy had a superior clinical benefit in patients with relapsed/refractory peripheral T-cell lymphoma vs existing treatments.