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Opinion|Videos|May 31, 2024

CAR T-Cell Therapy in R/R MM: Treatment Selection, Safety, and Future Perspectives

Author(s)Saad Z. Usmani, MD, MBA, FACP, Rahul Banerjee, MD, FACP, Doris Hansen, MD

Myeloma specialists have a comprehensive discussion on CAR T-cell therapy, highlighting treatment selection considerations, adverse event management strategies, unmet needs, and ongoing research.

Episodes in this series

A panel of 4 experts on multiple myeloma

EP. 1 The Rationale for CAR T-Cell Therapy in Relapsed/Refractory Multiple Myeloma

A panel of 4 experts on multiple myeloma

EP. 2 The Impact of CAR T-Cell Therapy on Relapsed/Refractory MM Treatment

A panel of 4 experts on multiple myeloma

EP. 3 How CAR T-Cell Therapy Impacts Relapsed/Refractory MM Treatment

A panel of 4 experts on multiple myeloma

EP. 4 Key Takeaways from the CARTITUDE-1 and KarMMa Studies

A panel of 4 experts on multiple myeloma

EP. 5 CAR T-Cell Therapy in R/R MM: Treatment Selection, Safety, and Future Perspectives

A panel of 4 experts on multiple myeloma

EP. 6 Insights from CARTITUDE-4 and KarMMa-3 in R/R MM

A panel of 4 experts on multiple myeloma

EP. 7 Future Perspectives on CAR T-Cell Therapy in Relapsed/Refractory MM

Video content above is prompted by the following questions:

Can you describe the ideal patient to receive cilta-cel vs ide-cel?
- In which patient populations would you not choose to give cilta-cel? Ide-cel?
- What is the role of patient preferences and shared decision-making when choosing between cilta-cel and ide-cel?

How does the safety profile factor into your treatment choice?
- What are the some commonly observed toxicities with CAR T-cell therapy?
- What are some strategies used to manage adverse events?

What are some challenges or barriers seen with CAR T-cell therapy?
- What are the logistical challenges associated with CAR T-cell therapy and what are the potential solutions?

What is the future of CAR T-cell therapy in relapsed/refractory multiple myeloma (R/R MM)?
- Please highlight any other trials of note investigating the use of cilta-cel or ide-cel for R/R MM.
- What other targets or dual targets are being investigated? (GPRC5D, CD19, BCMA, etc)

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