Gene Signature Identifies Low-Risk Patients in MAGE-A3 Trial
CHICAGO-It may be possible to identify non-small-cell lung cancer (NSCLC) patients with a high or low risk of relapse after surgery, according to findings presented at ASCO 2008 (abstract 7501).
CHICAGO-It may be possible to identify non-small-cell lung cancer (NSCLC) patients with a high or low risk of relapse after surgery, according to findings presented at ASCO 2008 (abstract 7501).
By analyzing data from a phase II trial of the investigational MAGE-A3 Antigen-Specific Cancer Immunotherapeutic (GlaxoSmithKline) in resected NSCLC, Johan F. Vansteenkiste, MD, PhD, of Catholic University, Leuven, Belgium, and colleagues were able to identify a gene signature predicting good prognosis. Overall, in the study, MAGE-A3 reduced the relative risk of recurrence by 25%, but in the population with a predicted low risk (gene signature positive), the risk reduction with MAGE-A3 was 43%.
The gene signature will be prospectively evaluated in the ongoing phase III MAGRIT study in MAGE-A3-positive NSCLC patients (stage Ib, II, and IIIA) who have undergone complete surgical resection, Dr. Vansteenkiste said.
Advancing Thoracic Surgery With Robotics and Video-Assisted Strategies
June 13th 2024"Anything that you can do to leverage technology to minimize the variability in surgery eliminates the skill gap so that novice surgeons may become as technically gifted as the intermediate surgeon or the master surgeon."
