Cisplatin Linked to Cardiac Complications in Testicular Ca Patients
Long-term survivors of testicular cancer treated with cisplatin-based chemotherapy have evidence of endothelial injury and dysfunction, compared with those who did not receive chemotherapy, according to a University of Pennsylvania study (Cancer 112:1949-1953, 2008).
Long-term survivors of testicular cancer treated with cisplatin-based chemotherapy have evidence of endothelial injury and dysfunction, compared with those who did not receive chemotherapy, according to a University of Pennsylvania study (Cancer 112:1949-1953, 2008). In the cross-sectional study, David J. Vaughn , MD, and colleagues assessed cardiovascular risk, subclinical atherosclerosis, and endothelial function in 24 long-term survivors. The cisplatin patients had reduced mean brachial artery flow-mediated dilatation and significantly higher mean soluble intercellular adhesion molecule-1 (SICAM-1) levels. Dr. Vaughn suggested that biomarkers of endothelial dysfunction could potentially identify asymptomatic long-term testicular cancer survivors who are at increased risk of cardiovascular events.
Evaluation and Management of Testicular Cancer After Late Relapse
The clinical quandary by Langer et al discusses a contralateral late relapse of the original right nonseminomatous germ cell tumors.
In this edition of Clinical Quandaries, Regina Barragan-Carrillo, MD, and colleagues present a case of an 18-year-old man who has a 1-month history of nonpainful right testicular enlargement.
