New Neupogen Formula More Temperature Stable

THOUSAND OAKS, Calif--A new formulation of Neupogen (filgrastim or G-CSF)that contains sorbitol instead of mannitol is now available from Amgen.

The new formulation has the same clinical safety and efficacy profileas the mannitol-containing version, but offers additional flexibility withrespect to storage parameters.

Sorbitol-containing Neupogen will remain stable even if exposed to freezingtemperatures, as might occur in transit. The recommended storage temperaturewill continue to be 2° to 8° C. However, the gel tray insulationand freeze watch indicators required with mannitol-containing Neupogenwill be eliminated, allowing for smaller packaging and reduced need forrefrigerator inventory space.