PSMA PET Imaging Agents: Image Quality and Diagnostic Performance

Opinion
Video

Panelists discuss how PSMA PET imaging utilizes various tracers, each with distinct properties influencing image quality and diagnostic accuracy. Fluciclovine F18 (Axumin) is primarily used for detecting recurrent prostate cancer, offering moderate sensitivity but lower specificity compared with PSMA-targeted agents. Gallium Ga-68 gozetotide (Illuccix) provides high sensitivity and specificity for prostate cancer lesions; however, its shorter half-life and limited availability may restrict widespread use. Piflufolastat F18 (Pylarify) combines the benefits of F18’s longer half-life with high image resolution, enhancing detection accuracy. Similarly, flotufolastat F18 (Posluma) leverages F18’s favorable imaging characteristics, offering high-quality images and reliable lesion detection.

Video content above is prompted by the following:

  • Present PSMA PET images using the available tracer agents, highlighting key similarities and differences in terms of image quality/resolution and accuracy.
    • Axumin PI (fluciclovine F18)
    • Illuccix PI (gallium Ga68 gozetotide)
    • Pylarify PI (piflufolastat F18)
    • Posluma (flotufolastat F18)
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