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Opinion|Videos|January 4, 2024

Future Directions in KRASG12C Mutated NSCLC

Author(s)Narjust Florez, MD

Narjust Florez, MD, discusses the complexities of treating KRAS mutations in NSCLC, including the challenges of commutations affecting immunotherapy response, the need for prolonged progression-free survival with KRAS inhibitors, dosage considerations, and highlights ongoing unmet needs and future research directions.

Episodes in this series

EP. 1 Current Treatment Landscape for KRASG12C-Mutated NSCLC

EP. 1 Current Treatment Landscape for KRASG12C-Mutated NSCLC

EP. 2 Treatment Options for KRASG12C Mutated NSCLC

EP. 2 Treatment Options for KRASG12C Mutated NSCLC

EP. 3 KRYSTAL-1: Follow-Up Data on Adagrasib Monotherapy in Patients with Advanced/Metastatic KRASG12C Mutated NSCLC

EP. 3 KRYSTAL-1: Follow-Up Data on Adagrasib Monotherapy in Patients with Advanced/Metastatic KRASG12C Mutated NSCLC

EP. 4 KRYSTAL-7: Efficacy and Safety of Adagrasib with Pembrolizumab in Patients With Advanced KRASG12C Mutated NSCLC

EP. 4 KRYSTAL-7: Efficacy and Safety of Adagrasib with Pembrolizumab in Patients With Advanced KRASG12C Mutated NSCLC

EP. 5 Long-Term Outcomes of Sotorasib Efficacy in Patients With KRASG12C Mutated NSCLC

EP. 5 Long-Term Outcomes of Sotorasib Efficacy in Patients With KRASG12C Mutated NSCLC

EP. 6 Hepatotoxicity with KRASG12C Inhibitors in NSCLC

EP. 6 Hepatotoxicity with KRASG12C Inhibitors in NSCLC

EP. 7 Sotorasib Versus Docetaxel for Previously Treated Patients With KRASG12C Mutated NSCLC: Data From CodeBreaK 200

EP. 7 Sotorasib Versus Docetaxel for Previously Treated Patients With KRASG12C Mutated NSCLC: Data From CodeBreaK 200

EP. 8 Managing CNS Metastases in KRASG12C Mutated NSCLC

EP. 8 Managing CNS Metastases in KRASG12C Mutated NSCLC

EP. 9 Future Directions in KRASG12C Mutated NSCLC

EP. 9 Future Directions in KRASG12C Mutated NSCLC

EP. 10 Experts Examine the Need for Targeted Therapy Options for KRAS G12C–Mutated NSCLC

EP. 10 Experts Examine the Need for Targeted Therapy Options for KRAS G12C–Mutated NSCLC

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