Cilta-cel May Offer Another Path in Previously Treated Multiple Myeloma
Treatment with cilta-cel may give patients with multiple myeloma “more time,” according to Ishmael Applewhite, BSN, RN-BC, OCN.
Rintatolimod/Durvalumab Dose Appears Tolerable in Pancreatic Cancer
Safety findings highlight no severe adverse effects or dose-limiting toxicities with the rintatolimod combination in late-stage pancreatic cancer.
FOLFIRI Plus ICIs Display Anti-Tumor Activity in Gastric/GEJ Cancer
Using FOLFIRI as a doublet with durvalumab or a triplet with durvalumab and tremelimumab yielded positive safety in gastric/GEJ cancers.
Addressing Peripheral Neuropathy Post–Cilta-cel in Multiple Myeloma
Nurses may need to help patients with multiple myeloma adjust to walking differently in the event of peripheral neuropathy following cilta-cel.
CHMP Promotes Positive Opinion of Amivantamab in EGFR Exon 20+ NSCLC
Amivantamab/chemotherapy has been recommended for approval by the CHMP in advanced non–small cell lung cancer with EGFR exon 20 insertion mutations.
FDA Approves Tisotumab Vedotin for Recurrent/Metastatic Cervical Cancer
Tisotumab vedotin-tftv may now be given to patients with recurrent or metastatic cervical cancer, according to the FDA.
Trastuzumab-strf Gets FDA Approval in Overexpressing Breast and Gastric Cancers
Patients with overexpressing breast and gastric cancers may now receive trastuzumab-strf, which has been approved by the FDA.
T-DXd Meaningfully Improves PFS Vs Chemo in HR+, HER2-Low Breast Cancer
Findings from the phase 3 DESTINY-Breast06 trial will be presented at a future medical meeting and shared with regulatory authorities.
Applying Novel Radiotherapy Technology for Brain Tumors and Other Cancers
Timothy Chen, MD, highlights how technologies such as ZAP-X and proton therapy may improve outcomes for patients with cancer.
EU’s CHMP Recommends Nivolumab Combo Approval in Urothelial Carcinoma
Findings from the CheckMate-901 trial support the CHMP’s positive opinion of nivolumab plus chemotherapy in metastatic urothelial carcinoma.
Early Intervention, Regular Assessment Can Grasp Symptom Course for Head and Neck Cancer Therapy
Nurses must increase the frequency of their assessments for early intervention of patients who undergo treatment for their head and neck cancer, in an effort to truly individualized care.
Mobile App May Facilitate GVHD Symptom Management
A mobile app may help to expedite treatment and identification for patients with GVHD.
Cancer Symptom Improvements Occur With Telehealth Exercise Program
Additional research may be necessary to validate the efficacy of telehealth interventions in clinical activities for patients with cancer.
Neoadjuvant Treatment Has Potential in Select CRC Populations
Administering neoadjuvant therapy to patients with colorectal cancer may help surgical oncologists attain a negative-margin resection.
Elderly Cancer Populations Have Inconsistent Symptom Burden/Clusters
Lack of energy, difficulty with sleeping, and pain were some of the most common symptoms reported in older patients with cancer.
ASCO Guideline Issues Updated Systemic Therapy Recommendations in HCC
Data from 10 new randomized clinical trials support updated recommendations for various systemic therapy regimens in hepatocellular carcinoma.
Defining a Nurse Coordinator’s Role During Outpatient CAR T-Cell Therapy
One of the most important roles of a nurse coordinator is transmitting patient and caregiver information during the CAR T-cell treatment process.
Identifying an optimal fludarabine exposure for improved outcomes after axi-cel therapy for aggressive B-cell non-Hodgkin lymphoma
Researchers from MSKCC have explored the potential of personalized fludarabine dosing, based on population pharmacokinetics, to enhance the outcomes of CD19 CAR T-cell therapy in patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphomas.
Early inflammatory markers as prognostic indicators following allogeneic stem cell transplantation
Researchers at the University of Birmingham in the UK have explored the dynamics of inflammatory biomarkers following allogeneic hematopoietic stem cell transplantation.
New Tocilizumab Workflow Is More Effective for CRS Related to CAR T, Bispecific Antibodies
A verbal tocilizumab workflow helped provide safer and more effective delivery of the agent for patients experiencing cytokine release syndrome.
Loncastuximab Tesirine Combo Is Effective, Safe in R/R Follicular Lymphoma
Loncastuximab tesirine and rituximab led to encouraging responses in most patients with relapsed/refractory follicular lymphoma in a single-center study.
Cilta-cel Yields Sustained Responses in R/R Multiple Myeloma
Findings from the CARTITUDE-2 trial support the use of cilta-cel in patients with multiple myeloma, says Tina Glow, AAS, RN, BSN.
Cilta-cel Shows High Responses for Lenalidomide-Refractory Myeloma in First Relapse
The latest CARTITUDE-4 data examine the efficacy and safety of ciltacabtagene autoleucel in lenalidomide-refractory multiple myeloma.
Cranial Nerve Palsy Present Across CARTITUDE Trials in Multiple Myeloma
Patients enrolled across the CARTITUDE trials who experienced cranial nerve palsy after treatment with cilta-cel were generally male.
Eftilagimod Alpha/Pembrolizumab Elicits Encouraging Responses in HNSCC
The phase 2b findings support the capability of eftilagimod alpha to enhance the potential of immune checkpoint inhibitors in metastatic HNSCC.
European Commission Approves Enzalutamide in nmHSPC Subset
Those with high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer can now receive enzalutamide in the European Union.
European Commission Approves Cilta-cel in R/R Multiple Myeloma
Findings from the phase 3 CARTITUDE-4 trial support the European approval of ciltacabtagene autoleucel for relapsed/refractory multiple myeloma.
FDA Grants Breakthrough Therapy Status to Ziftomenib in R/R NPM1+ AML
Findings from the KOMET-001 trial support the breakthrough therapy designation for ziftomenib in NPM1-mutated acute myeloid leukemia.
Dostarlimab Earns FDA Priority Review in All Advanced Endometrial Cancers
The FDA has set a Prescription Drug User Fee Act date of August 23, 2024, for dostarlimab in all types of primary advanced endometrial cancer.
Addressing the Growing Colorectal Cancer Incidence in Younger Populations
Increasing screening for younger individuals who are at risk of colorectal cancer may help mitigate the rising early incidence of this disease.