Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Richter Transformation: An International, Multicenter, Retrospective Study
ASTCT discusses Richter transformation and treatment options available for this population.
Nivolumab/Ipilimumab Yields Sustained Responses in Advanced HCC
The 5-year follow-up results from CheckMate 040 showed consistent responses with nivolumab/ipilimumab in advanced hepatocellular carcinoma.
FDA Approves Liso-cel in Relapsed/Refractory Mantle Cell Lymphoma
Findings from the TRANSCEND NHL 001 trial support the FDA approval of lisocabtagene maraleucel in relapsed/refractory mantle cell lymphoma.
Zanidatamab Earns FDA Priority Review in HER2+ Biliary Tract Cancer
The FDA has set a Prescription Drug User Fee Act date of November 29, 2024, for zanidatamab in this biliary tract cancer population.
Developing a Passion for Treating and Advancing Breast Cancer Care
Tiffany A. Traina, MD, FASCO, and Sherry Shen, MD, share their personal and professional journeys to becoming breast oncologists at Memorial Sloan Kettering Cancer Center.
42 Transitional Lymphedema: Understanding the Temporal Dynamics Post-Axillary Surgery
FDA Grants Priority Review to Inavolisib in HR+/HER2– PIK3CA+ Breast Cancer
The FDA has set a Prescription Drug User Fee Act date of November 27, 2024, for the inavolisib-based combination in this breast cancer population.
Selpercatinib Earns Accelerated Approval in Pediatric RET+ Thyroid Cancer
Data from the phase 1/2 LIBRETTO-121 trial led to the approval of selpercatinib in pediatric RET-mutant thyroid cancer.
AFM24/Atezolizumab Earns FDA Fast Track Status in EGFR Wild-Type NSCLC
Data from the phase 1/2a AFM24-102 trial support the fast track designation for the AFM24 combination in EGFR wild-type non–small cell lung cancer.
Achieving Precision With Radiation Oncology Advancements in NSCLC
The use of CT scans may help practices adaptively plan and adjust radiotherapy courses for patients with non–small cell lung cancer.
43 Impact of Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) on Postoperative Complication Rates in Mastectomy With Immediate Prosthetic-Based Breast Reconstruction
Assisted Reproductive Techniques Proven Safe in BRCA-Mutated Breast Cancer
Patients with BRCA-mutated breast cancer can safely undergo assisted reproductive techniques, according to an ESMO study.
Dato-DXd Improves Overall Survival Vs Chemo in Advanced Nonsquamous NSCLC
Investigators plan to present additional findings from the phase 3 TROPION-Lung01 trial at a future medical meeting.
Isatuximab Combo Earns FDA Priority Review in Transplant-Ineligible NDMM
The FDA has set a Prescription Drug User Fee Act Date of September 27, 2024, for the isatuximab combination in transplant-ineligible NDMM.
Minimizing Toxicity in NSCLC Management With Proton Beam Radiotherapy
Patients with NSCLC who have comorbidities or frailty may also be able to receive treatment with fewer toxicities via proton beam radiotherapy.
44 Variant of Uncertain Significance (VUS) Genetic Testing Results and Mastectomy Choice in Lumpectomy-Eligible Patients
Combining Immunotherapy With Radiation Oncology in NSCLC
Terrence T. Sio, MD, MS, emphasizes multidisciplinary collaboration for treating patients with NSCLC who may require more than 1 type of therapy.
Ensuring Quality Rectal Cancer Surgery at NAPRC-Accredited Institutions
Surgical oncologists from Cleveland Clinic discuss the National Accreditation Program for Rectal Cancer and its aim to improve patient outcomes.
Metformin Use Reduces MPN Diagnosis Risk
Metformin, a type 2 diabetes drug, was found to reduce myeloproliferative neoplasm development.
45 Application of the 7-Gene Biosignature in Palpable Versus Nonpalpable Ductal Carcinoma In Situ in a Black Patient Population: Does Palpability Suggest a More Aggressive Genomic Risk?
End-of-Life Chemo Yields No Survival Improvement in Advanced Solid Tumors
Data support revisiting goals of care conversations with patients with very advanced cancer who have significantly progressed with their disease.
46 Comparative Analysis of Breast Conserving Therapy vs Mastectomy in Multifocal and Multicentric Breast Cancer: A Review of the Literature
47 Can We Identify Factors That Predict DCIS Upgrade to Invasive Cancer at Mastectomy?
Complete Mesocolic Excision Appears Feasible in Right Colon Cancer
Treatment with complete mesocolic excision appears to reduce the length of hospital stay compared with conventional surgery in right colon cancer.
FDA Receives Rolling NDA for Avutometinib Combo in KRAS+ Ovarian Cancer
Data from the phase 2 RAMP 201 trial may support the potential accelerated approval of avutometinib/defactinib in KRAS-mutated LGSOC.
AI Tool May Increase Colonoscopy Reengagement
Investigators may continue to reevaluate the benefits of the AI navigator MyEleanor over time in other patient populations.
Pregnancy Attempts Appear Successful in Breast Cancer Population
Access to fertility preservation may help mitigate toxicity associated with chemotherapy and other agents in those with breast cancer.
Sociodemographic Disparities in Auto-HCT Exist for Black Myeloma Population
Despite increased education on autologous HCT, a lower rate of Black patients with multiple myeloma undergo treatment.
HPV Vaccinations May Decrease HPV-Related Cancers in Those Under 40
Rates of HPV-related cancers may be decreased in patients under 40 have received an HPV vaccine.
CEE Therapy Confers Ovarian Cancer Risk in Postmenopausal Population
Findings may support reconsideration of guideline recommendations concerning the use of estrogen alone in postmenopausal individuals.
