HIPEC is “Valid” Treatment Option in CRC Peritoneal Metastases
Quantifying disease volume to help identify potential recurrence following surgery may be a helpful advance, according to Sean Dineen, MD.
PBDE Exposure Confers Significant Cancer Mortality Risk
Further research may be needed to help determine the underlying mechanisms of polybrominated diphenyl ether exposure contributing to the risk of cancer-related mortality.
Pembrolizumab/MK-1084 Combo Is the Focus of Phase 3 Trial in KRAS G12C+ Metastatic NSCLC
MK-1084 previously demonstrated manageable safety and preliminary activity in non–small cell lung cancer harboring KRAS G12C mutations as part of a phase 1 trial.
Expert Highlights Importance of Palliative Care in Surgical Oncology
Sean Dineen, MD, highlights the removal of abdominal wall lesions and other surgical strategies that may help manage symptoms in patients with cancer.
Enfortumab Vedotin Combo Yields Significant Survival in Urothelial Cancer
Enfortumab vedotin plus pembrolizumab appears to reduce the risk of disease progression or death vs chemotherapy in locally advanced or metastatic urothelial carcinoma.
Novel Injection Earns FDA ODD in Breast Cancer Brain Metastases
Utidelone injection may cross the blood-brain barrier and help treat patients with breast cancer brain metastases.
Luspatercept Earns Expanded European Approval for Anemia in Lower-Risk MDS
Data from the phase 3 COMMANDS trial support the expanded European approval of frontline luspatercept for transfusion-dependent anemia in lower-risk myelodysplastic syndromes.
CRC-Associated Gene Alteration May Raise Likelihood of Other Solid Tumors
If possible, targeting the BER pathway for drug sensitivities may increase therapeutic options for managing solid cancers, wrote Channing Paller, MD.
Determining Personal and Professional Work/Life Balance in GU Oncology
Two women in genitourinary oncology discuss their experiences with figuring out when to begin a family and how to prioritize both work and children.
Utilizing a Multidisciplinary Team Approach to Bladder Cancer Treatment
Oncology pharmacists are important to the oncology care team, as they can bring a unique perspective to treatment planning, according to Kirollos S. Hanna, PharmD, BCPS, BCOP, FACC.
Personalized Vaccine Yields Early PFS Benefit in Metastatic MSS-CRC
Long-term circulating tumor DNA responses appear to align with progression-free survival trends in a phase 2/3 trial of the GRANITE vaccine in those with microsatellite-stable colorectal cancer.
FDA Accepts BLA for Dato-DXd in Metastatic HR+/HER2– Breast Cancer
Data from the phase 3 TROPION-Breast01 trial support the biologics license application for datopotamab deruxtecan in hormone receptor–positive, HER2-negative breast cancer.
Selecting Observation Vs Immunotherapy in Advanced Melanoma
Jonathan Zager, MD, spoke about the use of observation vs systemic immunotherapy to treat patients with stage IIIA and IIIB melanoma.
Observing the Evolving Prostate Cancer Landscape and Hopes for the Future
Over the past few decades, the prostate cancer space has evolved with increased funding for clinical trial creation and enrollment.
AEs to Monitor With Enfortumab Vedotin/Pembrolizumab in Advanced Bladder Cancer
Neuropathy is an adverse effect that can occur when enfortumab veodtin is administered to patients with locally advanced or metastatic urothelial carcinoma.
Ceramic Thyroid Ablation Needle Earns Class III Certificate in China
The characteristics of rare earth ceramics may yield more consistent microwave energy penetration during the treatment of those with thyroid nodules.
Afami-cel Demonstrates Enduring Responses in Pretreated Synovial Sarcoma
Findings from the phase 2 SPEARHEAD-1 trial demonstrate how T-cell receptor therapy may effectively target solid tumors.
Achieving Health Equity in Lung Cancer Surgery
Rian M. Hasson Charles, MD, MPH, FACS, discusses advances in equitable lung cancer screening and her experiences as a woman in thoracic oncology.
Updated ASCO Guideline Issues Vaccine Recommendations in Cancer Populations
An updated guideline from ASCO highlights appropriate use of vaccines for patients with cancer receiving treatments such as CAR T-cell therapy or B-cell depleting therapy.
Disadvantaged Areas Have Worse Cancer Surgery Access, Mortality
Data highlight that patients who are in Black and poor majority areas are less likely to receive liver ablation or colorectal liver metastasis in surgical cancer care.
Microbiome Signature Differences May Impact Rectal Cancer Treatment Effect
Gut microbiome signatures may lead the way for more accurate treatments and diagnoses for patients with colorectal cancer.
Data May Provide “Framework” for Mitigating Cancer Surgery Disparities
Findings highlight how systemic issues may impact disparities in outcomes following surgery for patients with cancer, according to Muhammad Talha Waheed, MD.
FDA Clears IND for Novel Molecular Glue in Advanced Solid Tumors
Investigators will evaluate the preliminary efficacy and safety of NST-628 in adult patients with solid tumors harboring mutations in the RAS-MAPK pathway as part of a phase 1 trial.
Enfortumab Vedotin Combo Earns Priority Review in China for Bladder Cancer
Data from the phase 3 EV-302 trial support an application for enfortumab vedotin plus pembrolizumab as a treatment for patients with advanced bladder cancer in China.
Adagrasib Significantly Improves PFS Vs Chemo in KRAS G12C-Mutated NSCLC
Treatment with adagrasib in the phase 3 KRYSTAL-12 trial raised no new safety signals among patients with KRAS G12C–mutated non–small cell lung cancer.
Novel CDK9 Inhibitor Yields Responses in Relapsed/Refractory AML
Responses with SLS009 were reported at 60 mg once weekly and 30 mg twice weekly for patients with relapsed/refractory acute myeloid leukemia.
Investigators Will Assess NXP800 in ARID1A-Mutated Ovarian Cancer
A phase 1b evaluating NXP800 in platinum-resistant ARID1A-mutated ovarian cancer is open for enrollment in the United Kingdom and the United States.
Ixabepilone Combo Improves PFS/OS in Platinum-Resistant Ovarian Cancer
Even when adjusting for prior taxane responses in patients with ovarian cancer, ixabepilone/bevacizumab appears to yield survival benefits in a phase 2 trial.
Capivasertib Combo Receives Approval in Japan for HR+/HER2– Breast Cancer
Findings from the phase 3 CAPItello-291 trial support the approval of capivasertib/fulvestrant for patients with hormone receptor–positive, HER2-negative breast cancer in Japan.
Pembrolizumab/Chemo Earns European Approval in Resectable NSCLC
Data from the phase 3 KEYNOTE-671 trial support the European Commission’s approval of pembrolizumab plus chemotherapy for those with resectable non–small cell lung cancer.