Database lists somatic EGFR mutations

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 17 No 5
Volume 17
Issue 5

GENEVA-A free online database brings together data on all of the known somatic mutations in EGFR, coupled with data on the response of NSCLCs treated with tyrosine kinase inhibitors, Samuel Murray, PhD, of Metropolitan Hospital, Athens, Greece, reported at the 1st European Lung Cancer Conference (abstract 750).

GENEVA-A free online database brings together data on all of the known somatic mutations in EGFR, coupled with data on the response of NSCLCs treated with tyrosine kinase inhibitors, Samuel Murray, PhD, of Metropolitan Hospital, Athens, Greece, reported at the 1st European Lung Cancer Conference (abstract 750). A literature search identified 202 eligible peer-reviewed articles on somatic mutations in EGFR pertaining to NSCLC. Of 12,244 screened NSCLC patients, 3,381 had EGFR mutations, including 254 different mutations. The database, which is updated every 6 months, is available at www.EGFR-mutations.org.

Recent Videos
STX-478 showed efficacy in patients with advanced solid tumors regardless of whether they had kinase domain or helical PI3K mutations.
Lisa J. States, MD, discussed further steps for improving early detection and screening methods in patients with Li–Fraumeni syndrome.
STX-478 may avoid adverse effects associated with prior PI3K inhibitors that lack selectivity for the mutated protein vs the wild-type protein.
9 Experts are featured in this series.
9 Experts are featured in this series.
Additional genetic testing measures and targeted therapies may improve outcomes for patients with diverse molecular subgroups of gastric cancers.
Phase 1 data may show the possibility of rationally designing agents that can preferentially target PI3K mutations in solid tumors.
Funding a clinical trial to further assess liquid biopsy in patients with Li-Fraumeni syndrome may help with detecting cancers early across the board.
Related Content