Minimal Residual Disease and a Treatment Option for MRD(+) CD19-Positive B-Cell Precursor Acute Lymphoblastic Leukemia

Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide, for BLINCYTO^®.

CancerNetwork^®’s podcast features Jennifer Caudle, MD, as she hosts Daniel DeAngelo, MD, to discuss the role of minimal/measurable residual disease testing in the treatment of patients with MRD(+) CD19-positive B-cell precursor acute lymphoblastic leukemia.

Host Dr. Jennifer Caudle
Guest Dr. Daniel DeAngelo

This program is intended for physicians. Amgen provided funding for this podcast and compensated the presenters for participating in this program. This program is not independent medical education and is not eligible for CME credit.

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Overview

When it comes to managing B-cell precursor acute lymphoblastic leukemia (ALL), there’s been growing discussion about the prognostic value of minimal/measurable residual disease (MRD). Research has found that the presence of MRD is a strong predictor of relapse, which may lead to poor patient outcomes. These findings not only support the importance of MRD testing, but treatment for those who test MRD(+).¹

Join Dr. Jennifer Caudle as she hosts Dr. Daniel DeAngelo, a medical oncologist from the Dana-Farber Cancer Institute in Boston and professor of medicine at Harvard Medical School, to discuss MRD testing and using BLINCYTO^® (blinatumomab) for the treatment of patients with CD19-positive B-cell precursor ALL who are MRD(+) after induction therapy.²

In this discussion, Dr. DeAngelo will review:

• How MRD is defined
• The most important reasons to test for MRD
• Data from the BLAST trial of BLINCYTO^®
• How BLINCYTO^® has impacted his practice

After listening to the discussion, visit www.blincytohcp.com to learn if BLINCYTO^® may be right for your patients with MRD(+) CD19-positive B-cell precursor ALL.

ALL = acute lymphoblastic leukemia; MRD = minimal/measurable residual disease; MRD(+) = minimal/measurable residual disease positive.

References

1. Brüggemann M, Gökbuget N, Kneba M. Acute lymphoblastic leukemia: monitoring minimal residual disease as a therapeutic principle. Semin Oncol. 2012;39(1):47-57.
2. BLINCYTO^® (blinatumomab) prescribing information, Amgen.