(P014) Age and Gender Patterns in the Use of Anesthesia for Children Receiving Radiotherapy

Publication
Article
OncologyOncology Vol 28 No 1S
Volume 28
Issue 1S

Complications in pediatric patients receiving anesthesia-assisted radiation therapy (AART) are rare, but the procedure is time-, space-, and resource-consuming. We analyzed our experience with AART for identifiable patterns regarding age and gender in children receiving daily proton radiation therapy.

Tara M. Hansen, MD, Kevin P. McMullen, MD, Jeffrey C. Buchsbaum, MD, PhD, Jennifer S. Bratton, RN, Peter A. Johnstone, MD, FACR; Indiana University School of Medicine

Objective: Complications in pediatric patients receiving anesthesia-assisted radiation therapy (AART) are rare, but the procedure is time-, space-, and resource-consuming. Influencing the decision to use AART may include ill-defined patient functional or psychological factors, as well as parent/physician discretion. We analyzed our experience with AART for identifiable patterns regarding age and gender in children receiving daily proton radiation therapy. 

Materials and Methods: After institutional review board (IRB) approval, we reviewed our records from the Indiana University Health Proton Therapy Center for patients requiring AART between January 9, 2004 and June 30, 2013 with respect to age and gender in our pediatric patients (defined as patients ≤ 18 years of age).

Results: A total of 390 pediatric patients were treated in this era. Of them, 182 were girls and 208 were boys. The median age at start of treatment for pediatric patients treated with AART was 4 years vs 13 years for those not requiring AART. Similarly, the median age at start of treatment for pediatric boys and girls treated with AART compared with those not requiring AART was 4 years vs 13 years and 3 years vs 12 years, respectively. Overall, the likelihood of requiring AART by age is shown in the figure. All children ≤ 3 years of age and the majority of children ≤ 6 years of age required AART. There was no significant difference in any age group by gender.

Conclusion: While children aged ≤ 3 years invariably require AART in our experience, not surprisingly, the need for AART decreases with increasing age. A small cadre of older children has functional or other issues that require them to receive AART for daily radiation treatment. There is no difference in AART requirement by gender. This pattern of care data may assist centers in preplanning needs for pediatric radiation therapy cases referred from distant referral sites. Additionally, it establishes a baseline curve for AART requirements in the pediatric population upon which future studies can build.

Articles in this issue

(P113) Age and Marital Status Are Associated With Choice of Mastectomy in Patients Eligible for Breast Conservation Therapy
(P112) Single-Institution Experience With Intrabeam IORT for Treatment of Early-Stage Breast Cancer
(P110) Breast Cancer Before Age 40: Current Patterns in Clinical Presentation and Local Management
(P111) Accelerated Partial-Breast Irradiation With Multicatheter High-Dose-Rate Brachytherapy: Feasibility and Results in a Private Practice Cohort
(P115) Breast Cancer Laterality Does Not Influence Overall Survival in a Large Modern Cohort: Implications for Radiation-Related Cardiac Mortality
(P117) Anatomical Variations and Radiation Technique for Breast Cancer
(P116) Bilateral Immediate DIEP Reconstruction and Postmastectomy Radiotherapy: Experience at a Tertiary Care Institution
(P118) Metadherin Overexpression Is Associated With Improved Locoregional Control After Mastectomy
(P119) Effect of Economic Environment on Use of Postlumpectomy Radiation Therapy for Stage I Breast Cancer
(P120) Immediate Versus Delayed Reconstruction After Mastectomy in the United States Medicare Breast Cancer Patient
(P121) Trend in Age and Racial Disparities in the Receipt of Postlumpectomy Radiation Therapy for Stage I Breast Cancer: 2004–2009
(P122) Streamlining Referring Physicians Orders With ‘Reflex Testing’ Significantly Decreases Time to Resolution for Abnormal Screening Mammograms
(P123) National Trends in the Local Management of Early-Stage Paget Disease of the Breast
(P124) Effect of Inhomogeneity on Cardiac and Lung Dose in Partial-Breast Irradiation Using HDR Brachytherapy
(P125) Breast Cancer Outcomes With Anthracycline-Based Chemotherapy for Residual Disease Burden After Full-Dose Neoadjuvant Chemotherapy and Surgery Followed by Radiation Treatment
Recent Videos
Educating community practices on CAR T referral and sequencing treatment strategies may help increase CAR T utilization.
Harmonizing protocols across the health care system may bolster the feasibility of giving bispecifics to those with lymphoma in a community setting.
Although accuracy remains a focus in whole-body MRI testing in patients with Li-Fraumeni syndrome, comfortable testing experiences may ease anxiety.
Subsequent testing among patients in a prospective study may affirm the ability of cfDNA sequencing to detect cancers in those with Li-Fraumeni syndrome.
cfDNA sequencing may allow for more accessible, frequent, and sensitive testing compared with standard surveillance in Li-Fraumeni syndrome.
STX-478 showed efficacy in patients with advanced solid tumors regardless of whether they had kinase domain or helical PI3K mutations.
STX-478 may avoid adverse effects associated with prior PI3K inhibitors that lack selectivity for the mutated protein vs the wild-type protein.
Phase 1 data may show the possibility of rationally designing agents that can preferentially target PI3K mutations in solid tumors.
Funding a clinical trial to further assess liquid biopsy in patients with Li-Fraumeni syndrome may help with detecting cancers early across the board.
Related Content