Role of Step-Up Dosing
Panelists discuss how this patient was admitted after the day 1 dose of talquetamab for observation for CRS and ICANS. Patients such as this are given a 0.01-mg/kg dose on the first day, a 0.06-mg/kg dose on day 3, and a 0.04-mg/kg dose on day 5 if there are no issues. The patient is then monitored for 48 hours and is discharged before getting the 0.08-mg/kg dose.
Video content above is prompted by the following:
- Can you describe the dosing regimen for talquetamab, both as an inpatient and outpatient?
- Please highlight why we decreased dosing frequency and what the data are telling us to do now?
- Given the toxicity associated with talquetamab, can you describe the conversations with the patients when giving the first dose of talquetamab?
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