An Overview of HER2 Alterations in NSCLC and Implications for Treatment
Panelists discuss how understanding the distinctions between HER2 overexpression and mutations in NSCLC influences patient care strategies and prognosis, alongside the challenges of biomarker testing methods such as IHC and NGS.
- Can you provide an overview of different HER2 alterations in NSCLC? What are the key differences between HER2 overexpression and HER2 mutations in NSCLC, in terms of biology and how we detect them? How do these distinctions impact our approach to patient care?
- How do prognoses and survival outcomes differ for patients with HER2-overexpressing NSCLC vs those with HER2-mutated NSCLC?
- Can you walk us through your biomarker testing practices in NSCLC, particularly for identifying HER2 overexpression vs HER2 mutations? What are the challenges and considerations specific to each testing approach in NSCLC (IHC vs NGS testing)?
- How do you balance the need for comprehensive biomarker testing with the limitations of tissue availability?
NCCN Guideline Updates in HR+ Breast Cancer: Focus on Extended Adjuvant Therapy
August 17th 2021This article reviews NCCN Guideline updates regarding the use of genomic assays in predicting the benefit of extended adjuvant endocrine therapy in patients with HR+ breast cancer and includes insights from Lee S. Schwartzberg, MD, of West Cancer Center at the University of Tennessee Health Science Center in Memphis, TN.
Individualizing Extended Adjuvant Therapy in HR+ Breast Cancer
June 15th 2021This article reviews individualizing extended adjuvant therapy for patients with HR+ breast cancer and includes insights from Vijayakrishna (V. K.) Gadi, MD, PhD, of the University of Illinois in Chicago, and Reshma L. Mahtani, DO, of the University of Miami Health System in Deerfield Beach, FL.
Advances in Later-Line Management of Relapsed/Refractory Follicular Lymphoma
May 27th 2021This article reviews advances in later-line management of relapsed/refractory follicular lymphoma. This article also features insights from oncology expert Sameh Gaballa, MD, of Moffitt Cancer Center in Tampa, Florida.
