Approved and Investigational Agents for Myelofibrosis

Panelists discuss how Janus kinase (JAK) inhibitors, including ruxolitinib, fedratinib, pacritinib, and momelotinib, as well as investigational agents like pelabresib and navitoclax, target the dysregulated JAK-STAT pathway to manage symptoms and potentially modify disease progression in myelofibrosis.

EP: 1.Myelofibrosis: Background, Risk Stratification, and Treatment Decision-Making

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EP: 2.Approved and Investigational Agents for Myelofibrosis

EP: 3.Disease Modification Strategies and Unmet Needs in Myelofibrosis

EP: 4.MANIFEST-2: Pelabresib in Myelofibrosis: MOA, Study Design, and Spleen Volume Reduction

EP: 5.Disease- Modifying Biomarker Data in the MANIFEST-2 Study Investigating Pelabresib

EP: 6.Safety Profile of the Pelabresib and Ruxolitinib Combination in Myelofibrosis

EP: 7.Pelabresib in MPNs: Immune Profiles of Responders vs. Non-responders

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