Efficacy of Immunotherapies for dMMR or MMRp Advanced/Recurrent Endometrial Cancer

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The panel discusses their opinions on the use of immunotherapy in different populations of women with advanced/recurrent endometrial cancer.

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Findings from the OVARIO study show that patients with HRR–deficient and BRCA-mutated disease benefitted the most from niraparib/bevacizumab maintenance.
Select comorbidities, ECOG status, and the receipt of radiation were among the differences between a real-world cohort and the RUBY trial population.
Next-generation clinical trials may address when to use CDK4/6 inhibition in patients with low-grade serous ovarian cancer.
The NRG-GY019 trial will assess chemotherapy plus letrozole vs letrozole alone as a frontline treatment for patients with low-grade serous ovarian cancer.
Nearly 40% of low-grade serous ovarian cancers have RAS alterations, which are predominately KRAS mutations.
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Social Determinants of Health Negatively Affected Endometrial Cancer Diagnosis

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Factors such as language spoken, social vulnerability index characteristics, and insurance type were found to alter endometrial cancer diagnoses and led to worse outcomes.

Uterine transposition, a surgical approach preserving fertility by moving the uterus out of the radiation field, may improve gynecologic cancer outcomes.

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Certain subpopulations experienced significantly poorer outcomes in 2020, highlighting concerns regarding access to care.

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Niraparib/Bevacizumab Maintenance Prolongs Response in Pretreated Ovarian Cancer

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Ariana Pelosci
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Results from the NIRVANA-R trial found niraparib/bevacizumab maintenance yielded positive activity in pretreated ovarian cancer.