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CIRCULATE-Japan GALAXY: ctDNA-Based MRD Detection in Colorectal Cancer and Implications for Survival, Treatment, and Risk Stratification

GALAXY Study Results: ctDNA Status Predicts Outcomes and Treatment Benefit in CRC

Videos

Mike J. Pishvaian, MD, PhD; Stacey Cohen, MD; and Mark Lewis, MD, FASCO, discuss how recent advancements in circulating tumor DNA (ctDNA) and minimal residual disease (MRD) testing are revolutionizing colorectal cancer management across the care continuum, from early detection to treatment selection and monitoring, with key insights from major clinical trials like DYNAMIC and GALAXY informing more personalized and effective treatment strategies.

Panelists discuss how colorectal cancer rates are increasing, particularly among younger adults, while highlighting the potential of circulating tumor DNA (ctDNA) technology to improve early detection and treatment monitoring.

Colorectal Cancer: Rising Prevalence and the Promise of ctDNA

Panelists discuss how circulating tumor DNA (ctDNA) is revolutionizing colorectal cancer (CRC) management by enabling more personalized and precise approaches to diagnosis, treatment selection, and monitoring of disease progression.

ctDNA in CRC Management: Evolving Approaches for Personalized Care

Panelists discuss how minimal residual disease (MRD) detection in colorectal cancer (CRC) is improving postsurgical treatment decision-making and enabling more effective monitoring of patient outcomes.

MRD Detection in CRC: Guiding Postsurgical Treatment Decisions and Monitoring

Panelists discuss how minimal residual disease (MRD) testing in colorectal cancer (CRC) is facilitating the development of chemo-sparing strategies while maintaining effective control of residual disease.

MRD Testing in CRC: Optimizing Chemo-Sparing Strategies and Residual Disease Control

Panelists discuss how the DYNAMIC trial data demonstrate the potential of circulating tumor DNA (ctDNA)–guided therapy to inform and optimize adjuvant chemotherapy decisions in patients with stage II colon cancer.

DYNAMIC: ctDNA-Guided Therapy on Adjuvant Chemotherapy Decisions in Stage II Colon Cancer

Panelists discuss how insights from the INTERCEPT, BESPOKE, COSMOS-CRC-01, and GALAXY studies are advancing our understanding of circulating tumor DNA’s (ctDNA) utility in colorectal cancer management, from early detection to treatment monitoring.

ctDNA Insights From INTERCEPT, BESPOKE, COSMOS-CRC-01, and GALAXY Studies

Panelists discuss how the GALAXY study data demonstrate the effectiveness of circulating tumor DNA (ctDNA)–based minimal residual disease (MRD) monitoring in patients with resected colorectal cancer (CRC), potentially improving postsurgical care and outcomes.

GALAXY Study: ctDNA-Based MRD Monitoring in Resected CRC

Panelists discuss how results from the GALAXY study reveal that circulating tumor DNA 
(ctDNA) status is a powerful predictor of outcomes and treatment benefit in patients with colorectal cancer (CRC), potentially revolutionizing personalized treatment approaches.


Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

GALAXY Study Results: ctDNA Status Predicts Outcomes and Treatment Benefit in CRC

EP: 1.Colorectal Cancer: Rising Prevalence and the Promise of ctDNA

EP: 2.ctDNA in CRC Management: Evolving Approaches for Personalized Care

EP: 3.MRD Detection in CRC: Guiding Postsurgical Treatment Decisions and Monitoring

EP: 4.MRD Testing in CRC: Optimizing Chemo-Sparing Strategies and Residual Disease Control

EP: 5.DYNAMIC: ctDNA-Guided Therapy on Adjuvant Chemotherapy Decisions in Stage II Colon Cancer

EP: 6.ctDNA Insights From INTERCEPT, BESPOKE, COSMOS-CRC-01, and GALAXY Studies

EP: 7.GALAXY Study: ctDNA-Based MRD Monitoring in Resected CRC

EP: 8.GALAXY Study Results: ctDNA Status Predicts Outcomes and Treatment Benefit in CRC