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Prevent Infusion-Related Reactions With Intravenous Amivantamab: Primary Results From SKIPPirr, a Phase 2 Study

Key Takeaways and Clinical Pearls from SKIPPirr

Videos

Panelists discuss managing infusion-related reactions with amivantamab and lazertinib, compare these reactions with those from other treatments, and review SKIPPirr data to provide insights on incorporating prophylactic dexamethasone 8 mg, addressing implementation barriers, and educating patients.

Panelists discuss how amivantamab, FDA approved for first-line treatment of advanced non–small cell lung cancer with specific EGFR mutations, can lead to significant infusion-related reactions, including serious cases that may require dose adjustments or discontinuation.

The Role of Amivantamab Plus Lazertinib for NSCLC

Panelists discuss the frequency, timing, and symptoms of infusion-related reactions with amivantamab plus lazertinib, how these drugs compare with other treatments such as datopotamab deruxtecan (DXd) or patritumab DXd (HER3-DXd), and the management strategies and prophylactic measures used, especially for patients with EGFR exon 19 or L858R advanced/metastatic non–small cell lung cancer who have experienced progression on prior therapies.

Treatment-Related IRRs for Patients on Amivantamab Plus Lazertinib

Panelists discuss the clinical implications of the SKIPPirr trial data presented at the 2024 World Congress on Lung Cancer, including whether it  might reduce resistance to using this combination  in practice, how to implement supportive measures such as prophylactic dexamethasone 8 mg, potential barriers to implementation, strategies to overcome these barriers, and ways to educate patients about infusion-related reactions and the benefits of prophylactic measures.

Updates on the SKIPPirr Trial

Panelists discuss other adverse events associated with amivantamab and lazertinib beyond infusion-related reactions.

Prophylactic Management of IRRs With Amivantamab Plus Lazertinib for NSCLC

Panelists discuss key takeaways from the analysis and offer clinical pearls on incorporating prophylactic dexamethasone 8 mg into treatment with amivantamab and lazertinib for community colleagues.

Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

Key Takeaways and Clinical Pearls from SKIPPirr

EP: 1.The Role of Amivantamab Plus Lazertinib for NSCLC

EP: 2.Treatment-Related IRRs for Patients on Amivantamab Plus Lazertinib

EP: 3.Updates on the SKIPPirr Trial

EP: 4.Prophylactic Management of IRRs With Amivantamab Plus Lazertinib for NSCLC

EP: 5.Key Takeaways and Clinical Pearls from SKIPPirr