Second-Line Treatment for R/R Multiple Myeloma: Who Is the “Right Patient”?

Opinion
Video

Panelists discuss how, for second-line treatment of relapsed/refractory multiple myeloma (R/R MM), patients suitable for CAR T-cell (cilta-cel vs ide-cel) therapy typically have a poor prognosis with limited response to prior therapies. Institutional guidelines focus on factors such as prior lines of therapy, organ function, and cytogenetics. Non-medical factors, such as geographic access and financial constraints, also influence CAR T-cell therapy referral eligibility.

Video content above is prompted by the following:

  • Which patients do you consider for CAR T-cell therapy in second-line treatment for R/R MM (cilta-cel vs ide-cel)?
  • Can you describe the specific criteria/institutional guidelines used to determine patient eligibility for CAR T-cell therapy referral?
  • How do nonmedical factors (location, money, etc) impact patient selection?
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