Sunitinib Improves Progression-Free Survival in Patients With Advanced Pancreatic Islet Cell Tumors

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OncologyONCOLOGY Vol 23 No 8
Volume 23
Issue 8

Pfizer announced results from a randomized phase III trial of sunitinib malate (Sutent) in patients with advanced pancreatic islet cell (neuroendocrine) tumors

Pfizer announced results from a randomized phase III trial of sunitinib malate (Sutent) in patients with advanced pancreatic islet cell (neuroendocrine) tumors. Study findings demonstrated that median progression-free survival was 11.1 months in patients treated with sunitinib compared to 5.5 months in patients treated with placebo. Researchers presented these data at the 11th World Congress on Gastrointestinal Cancer in Barcelona, Spain.

The independent Data Monitoring Committee recommended halting the trial earlier this year because sunitinib showed significant benefit and the study had met its primary endpoint. Full analysis of the data is ongoing.

Articles in this issue
Resolving Confusion: The New Realities of Mantle Cell Lymphoma
Something Old, Something New: Options for Treating Relapsed Mantle Cell Lymphoma
Supraclavicular Extraskeletal Myxoid Chondrosarcoma Presenting With a Sensorimotor Polyneuropathy Associated With Anti-Hu Antibodies
Supraclavicular Extraskeletal Myxoid Chondrosarcoma Presenting With a Sensorimotor Polyneuropathy Associated With Anti-Hu Antibodies
Reishi Mushroom
Reishi Mushroom
Unraveling the Mystery of a Supraclavicular Mass
Management of Relapsed Mantle Cell Lymphoma: Still a Treatment Challenge
Sunitinib Improves Progression-Free Survival in Patients With Advanced Pancreatic Islet Cell Tumors
Phase III Trial Initiated for BLP25 Liposome Vaccine in Breast Cancer Patients
US Oncology Launches Oncology-Specific EHR
Effective Local Therapy and Long-Term Survival in Breast Cancer
Local Therapy Matters
Deemphasize Dogma: Consider the Local Control–Overall Survival Link
Romiplostim for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura
The Road to Romiplostim Approval and Beyond
The REMS Publication Paradox
Recent Videos
Differences in pancreatic cancer responses to treatment elicits a need to better educate patients on expectations in treatment, particularly chemotherapy.
Increasing patient awareness of modifiable risk factors for pancreatic cancer may help mitigate incidence of pancreatic cancers.
It may be crucial to test every patient for markers such as BRAF V600E mutations, NRG1 fusions, and KRAS G12C mutations to help manage pancreatic cancers.
Tanios S. Bekaii-Saab, MD, emphasizes the idea of moving targeted therapies to earlier lines of treatment to further improve outcomes in pancreatic cancer.
Experts from Vanderbilt University Medical Center emphasize gathering a second opinion to determine if a tumor is resectable in patients with pancreatic cancer.
Experts from Vanderbilt University Medical Center discuss the use of intraoperative radiation therapy in a 64-year-old patient with pancreatic cancer.
Investigators are assessing the use of IORT in patients with borderline resectable or unresectable pancreatic cancer as part of the phase 2 PACER trial.
Kamran Idrees, MD, MSCI, MMHC, FACS, discusses how factors such as vessel involvement can influence the decision to proceed with surgical therapy.
Milad Baradaran, PhD, DABR, outlines the design of Mobetron as an option for administering intraoperative radiation therapy in pancreatic cancer care.
Intraoperative radiation therapy may allow surgical and radiation oncologists to collaboratively visualize at-risk areas in patients with cancer.
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