Lung Cancer

Cancer Network spoke with Lecia V. Sequist, MD, MPH, about the TATTON study, which tested the combination of osimertinib and savolitinib in previously treated non–small-cell lung cancer patients.

A pooled analysis of two trials presented at the AACR Annual Meeting looked at the use of pembrolizumab in patients with heavily pretreated extensive small-cell lung cancer.

The revised version focuses on the first-line use of immunotherapy and the measurement of tumor cells expressing PD-L1.

In this article, we review the new developments in neoadjuvant therapy for lung cancer.

Researchers' findings on the efficacy of a liquid biopsy test called Guardant360 vs standard tissue biopsies will be presented at AACR 2019.

A trial showed that tumor mutational burden may be effective as a biomarker in patients treated with immunotherapy.

Researchers studied the combination of a cellular vaccine known as HS-110 and nivolumab in an early-phase trial of patients with advanced non–small-cell lung cancer.

Results of the 2-year follow-up analysis of the pivotal KEYNOTE-024 trial were recently published in the Journal of Clinical Oncology.

Two new studies found that targeting the cyclin-dependent kinases 4/6 exposed a vulnerability in SMARCA4-deficient cancers.

A set of simple interventions succeeded in reducing disparities in lung cancer care between black and white patients across five cancer centers.

The large precision medicine trial known as Lung-MAP has announced it will expand to patients with all non–small-cell lung cancers, accounting for as many as 85% of all lung cancer diagnoses in the US.

The results, described by an expert as “very interesting” and a “a bit surprising," focused on the impact of autoimmune antibodies on anti–PD-1 therapy.

The phase III CONVERT trial compared twice-daily vs once-daily concurrent chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer.

A surprisingly low percentage of Medicare enrollees who undergo low-dose CT screening for lung cancer participate in a shared decision-making session prior to the screening.

Researchers investigated whether first-line chemotherapy improved overall survival in NSCLC patients with severe to very severe COPD.

Researchers evaluated the survival benefit of adding pembrolizumab to chemotherapy with carboplatin plus paclitaxel or nab–paclitaxel compared with chemotherapy alone.

The long-term results from an analysis of two phase II studies confirmed the role of osimertinib in the treatment of T790M mutation–positive advanced non–small-cell lung cancer.

Researchers found that patients with stage I/II lung cancer have relatively long-term survival when treated with chemoradiotherapy, calling into question the practice of combining these patients with stage III patients.

In this phase II trial, researchers tested the efficacy of lorlatinib in six expansion cohorts of NSCLC patients based on ALK mutation status and prior treatment.

This trial looked at the efficacy of nivolumab in a cohort of patients who were evaluated for KRAS mutations to test whether mutation status had an effect on outcomes.

The ABOUND.2L+ trial tested the combination of nab-paclitaxel and CC-486 vs single-agent nab-paclitaxel in patients with advanced NSCLC.

This article discusses ways in which the oncologist can incorporate value into the management of patients with lung cancer and comply with the underlying principles of the Choose Wisely Campaign, as well as recent ASCO and ESMO initiatives, to bend the cost curve downwards while maintaining efficacy.

Experts discuss the implications of research that found PCI reduces brain metastases in stage III NSCLC, but does not improve overall survival.

Researchers reported on differences in overall survival for LCT vs maintenance therapy/observation in oligometastatic NSCLC.

Many lung cancer patients may be unaware of the potential benefits of exercise.

Previous research showed that gefitinib can improve DFS in certain NSCLC patients, raising the possibility that EGFR-targeted TKIs could be beneficial in the neoadjuvant setting.

Due to the high rate of EGFR T790M mutations seen in NSCLC patients, the thoracic tumor board recommends genomic testing for this alteration; read our case of a 69-year-old woman with metastatic disease.

Avelumab did not improve overall survival compared with docetaxel in patients with PD-L1–positive non–small-cell lung cancer.

A study shows NSCLC patients who undergo minimally invasive procedures are less likely to use opioids long-term.

In recent years, advances in the molecular analysis of tumors and pathologic investigation have improved understanding of an ambit of lung cancer types.