Adagrasib Shows Promise in Phase 1/2 Trial for KRAS G12C Mutated NSCLC, CRC, and Other Solid Tumors
November 24th 2020Adagrasib demonstrated an acceptable safety profile and promising clinical activity in pretreated patients with non-small cell lung cancer, colorectal cancer, and other solid tumors with a KRAS G12C mutation.
Oncology Peer Review On-The-Go: Fertility Preservation Decision-Making for Adolescents with Cancer
November 24th 2020The latest episode of the journal ONCOLOGY’s podcast features an article published in the November issue discussing fertility preservation and decision-making for young adults with cancer.
UDCA May Be Associated with Reduction of Biliary Tract Cancer, Need for Liver Transplantation
November 24th 2020Data from a Japanese cohort of patients with primary sclerosing cholangitis suggested ursodeoxycholic acid (UDCA) was significantly associated with reduced mortality or need for liver transplantation and was also likely to be associated with a reduction of biliary tract cancer.
Phase 3 CROWN Trial Shows Promise for Lorlatinib in Previously Untreated ALK-Positive NSCLC
November 23rd 2020An interim analysis of the trial revealed that among patients with previously untreated advanced ALK-positive non-small cell lung cancer, those who received lorlatinib (Lorbrena) had significantly longer PFS, a higher overall and intracranial response, and better quality of life.
Phase 3 IMCgp100-202 Trial of Tebentafusp Shows Promise for Metastatic Uveal Melanoma
November 23rd 2020The clinical trial of tebentafusp (IMCgp100) versus investigator’s choice in metastatic uveal melanoma met its pre-defined boundaries for statistical significance of the primary end point of overall survival in its first pre-planned interim analysis.
Osimertinib Extends Disease-Free Survival in Resected EGFR-Mutated NSCLC in Phase 3 ADAURA Trial
November 21st 2020These study results suggest that osimertinib as adjuvant therapy is an effective treatment strategy for patients with stage IB to IIIA EGFR-positive non-small cell lung cancer following complete tumor resection.
Ipilimumab Plus Nivolumab Promising for Patients with Metastatic or Unresectable Angiosarcoma
November 21st 2020A study presented at The Society for Immunotherapy of Cancer’s (SITC) 35th Anniversary Annual Meeting suggested that ipilimumab (Yervoy) plus nivolumab (Opdivo) for patients with metastatic or unresectable angiosarcoma was well-tolerated.
Steven M. Dubinett, MD, on Early Lung Cancer Development and Testing Methods
November 20th 2020The SU2C–LUNGevity Foundation–American Lung Association Lung Cancer Interception Dream Team have developed laboratory models to understand the inflammatory process in the lung’s bronchial cells, and how that relates to early lung cancer development.
Increase in Early-Stage Cancer Diagnoses Tied to ACA’s Medicaid Expansion, Pitt Study Finds
November 20th 2020A study published in American Journal of Preventative Medicine found that expansion of the Affordable Care Act resulted in an increase in early-stage cancer diagnoses and a decrease in late-stage cancer rates for patients.
FDA Approves Additional Dosing Option of Durvalumab for Stage III NSCLC, Advanced Bladder Cancer
November 20th 2020The FDA approved a 1500 mg fixed dose of durvalumab (Imfinzi) administered every 4 weeks for the treatment of unresectable stage III non-small cell lung cancer after chemoradiation therapy and previously treated advanced bladder cancer.
Study Suggests Axillary Surgery Not Necessary for All Women with Invasive Breast Cancer
November 19th 2020“In the current era of effective multimodality therapy for breast cancer, the need for [axillary lymph node dissection] for patients with axillary lymph node metastases must be re-evaluated, even for patients with clinically positive nodal disease,” the study authors wrote.
Study Finds Assisted Reproductive Technology Does Not Lead to Increased Risk of Ovarian Cancer
November 18th 2020This study found that the increased risk of ovarian cancer in women treated with assisted reproductive technology compared with the general population can likely be explained by nulliparity instead.
Phase 3 RATIONALE 303 Meets Primary End Point of OS in NSCLC
November 18th 2020The clinical trial is designed to evaluate the efficacy and safety of tislelizumab compared to docetaxel in the second- or third-line setting in patients with locally advanced or metastatic non-small cell lung cancer who have progressed on a prior platinum-based chemotherapy.
Ongoing Phase 1/2 Trial of FLX475 Shows Promising Activity in Multiple Cancer Indications
November 17th 2020The results demonstrated preliminary evidence of monotherapy activity, encouraging efficacy in combination with the PD-1 checkpoint inhibitor pembrolizumab (Keytruda), and biomarker data supporting FLX475’s mechanism of action.
FDA Will Not Complete Review of BLA for Lisocabtagene Maraleucel By PDUFA Date
November 17th 2020The priority review of the biologics license application for lisocabtagene maraleucel (liso-cel) for the treatment of adults with relapsed or refractory large B-cell lymphoma after at least 2 prior therapies will not be completed by the prescription drug user fee act date.