MTX110 May Show Survival Benefits in Recurrent Glioblastoma
Investigators are assessing the feasibility, safety, and efficacy of MTX110 for patients with recurrent glioblastoma as part of the phase 1 MAGIC-1 study.
ctDNA Clearance Confers Responses to Radiation in Gynecologic Malignancies
ctDNA reductions or clearance also appeared to correlate with a decrease in disease burden during the pre-boost phase of radiotherapy.
Complete Consolidative Radiotherapy May Have Survival Benefits in ES-SCLC
Offering certain radiotherapy modalities based on disease burden may play a role in the outcomes of those with ES-SCLC, according to James Ninia, MD.
Assessing ctDNA as a Predictor of RT Responses in Gynecologic Cancers
Investigators evaluated ctDNA as a potentially noninvasive method to predict response to radiotherapy among those with gynecologic malignancies.
FDA Approves Zolbetuximab in Advanced CLDN18.2+ Gastric/GEJ Adenocarcinoma
Data from the phase 3 SPOTLIGHT trial and the phase 3 GLOW trial supported the approval of zolbetuximab plus chemotherapy in this indication.
Financial Toxicity More Prevalent in Adolescents, Young Adults With Cancer
Adolescents and young adults with cancer more commonly experience financial toxicity and unmet social needs.
Avutometinib Combo Yields Responses in Low-Grade Serous Ovarian Cancer
Updated findings from RAMP 201 show that avutometinib/defactinib is generally well tolerated among those with low-grade serous ovarian cancer.
Pathogenic Variants Lead to Better Attitudes, Engagement in Genetic Testing
Those with pathogenic variants had a higher likelihood of communicating with clinicians and family members about test results.
Reflexology Reduces Stress/Pain, Increases Energy During Breast Cancer RT
Study findings reveal that patients with breast cancer reported overall improvement in their experience when receiving reflexology plus radiotherapy.
Evaluating Reflexology Impact on Breast Cancer RT-Related Anxiety, Pain
Patients undergoing radiotherapy for breast cancer were offered 15-minute nurse-led reflexology sessions to increase energy and reduce stress and pain.
RT May Affect Scholastic Performance in Pediatric Brain Tumor Survivors
Raymond B. Mailhot, MD, MPH, discussed how radiation therapy can impact education and survivorship for pediatric survivors of brain tumors.
Nivolumab Combo Improves PFS in Stage III/IV Advanced Hodgkin Lymphoma
Phase 3 data show that nivolumab/AVD may also reduce long-term toxicities vs brentuximab vedotin/AVD in advanced Hodgkin lymphoma.
Ultra-Hypofractionated RT Shows Control, Tolerability in Elderly Breast Cancer
Bin Gui, MD, discussed how ultra-hypofractionated radiotherapy may be a convenient treatment option for elderly patients with early breast cancer.
Prescribing Patterns Vary With Opioid Use for Cancer-Related Pain Management
Review data demonstrated a variation in opioid prescriptions for cancer-related pain between oncology providers and pain management providers.
Cisplatin Shortage Shifted Chemo Utilization to Costlier Therapies for HNC
While cisplatin was in shortage, clinicians were forced to prescribe costlier alternatives for patients with head and neck cancer.
FDA Accepts New Drug Application for UGN-102 for Bladder Cancer
The decision is backed by robust efficacy data from the phase 3 ENVISION trial, evaluating UGN-102 in patients with non-muscle invasive bladder cancer.
Osimertinib/Savolitinib Shows Meaningful Responses in EGFR+ NSCLC
Data from the phase 2 SAVANNAH trial may support savolitinib as a new treatment option following standard-of-care osimertinib in EGFR-mutated NSCLC.
Despite Great Strides, Much Work Remains in GYN Cancer Outcomes and Care
Ginger J. Gardner, MD, FACOG, walked through the strides of gynecologic cancer research and emphasized the efforts that still need to be accomplished.
RT Therapy for Brain Tumors May Negatively Impact Processing Speed
Significant results from a retrospective analysis of brain tumor survivor academic performance after radiotherapy emerged despite small sampling size.
FDA Approves TTFields for Previously Treated Metastatic NSCLC
Support for the approval comes from phase 3 LUNAR study findings indicating TTFields significantly prolonged OS compared with standard of care alone.
Lurbinectedin Combo Yields Significant OS/PFS in ES-SCLC
Developers plan to submit a supplemental NDA for this combination as a first-line maintenance therapy for ES-SCLC in the first half of 2025.
Taste Change Data May Inform Radiotherapy Strategy in Head and Neck Cancer
Findings may help providers and patients with head and neck cancer consider whether to proceed with radiotherapy modalities, such as proton therapy or IMRT.
Cancer Vaccine Combo Does Not Improve PFS in Cervical/Anogenital Tumors
Subgroup data indicate a positive efficacy trend for TG4001 plus avelumab among patients with cervical cancer.
Evaluating Scholastic Performance in Brain Cancer Survivors Following RT
Raymond B. Mailhot, MD, MPH, discussed methods for comparing academic performances of patients following radiation therapy with healthy control groups.
Data Show Substantial Taste Changes in Head and Neck Cancer Following RT
Study results appear to affirm anecdotal information from patients with head and neck cancer related to taste changes during and after radiotherapy.
Measuring Objective Taste Changes in Head and Neck Cancer Population After RT
Noah S. Kalman, MD, MBA, describes the rationale for using a test to measure granular details of taste change in patients undergoing radiotherapy for HNC.
5-FU Bolus Omission May Reduce Toxicity, Maintain Efficacy in GI Cancers
Omitting bolus 5-fluouracil in chemotherapy-based treatment for patients with gastrointestinal cancers may reduce adverse effects and healthcare costs.
PRAME-Targeted Agent Shows Activity in Pretreated Metastatic Melanoma
Phase 1b findings may affirm the therapeutic potential of IMA203 for patients with previously treated metastatic melanoma.
Fianlimab Combo Shows Activity in Advanced Melanoma Subtypes
The safety profile of fianlimab/cemiplimab in a phase 1 trial was consistent with prior reports of cemiplimab monotherapy.
Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma
Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.