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Lenvatinib Plus Pembrolizumab vs Sunitinib in Advanced Renal Cell Carcinoma: Patterns of Progression and  Subsequent Therapy in the CLEAR Trial

Video Series

Clinical Decision MakingDecision-making With TKI-IO Combinations for Advanced RCC

Videos

Panelists discuss how the CLEAR trial highlights the efficacy of lenvatinib plus pembrolizumab over sunitinib in advanced renal cell carcinoma, focusing on patterns of progression and the implications for subsequent therapy.

Panelists discuss how the evolving first-line treatment landscape for advanced renal cell carcinoma is shaped by novel immunotherapy combinations, including lenvatinib plus pembrolizumab, and the impact of these therapies on patient outcomes and progression patterns.

1L Treatment Landscape for Advanced Renal Cell Carcinoma

Panelists discuss how metastatic site–specific outcomes with first-line therapies for clear cell renal cell carcinoma (ccRCC) provide insights into the efficacy of treatment strategies based on the location of metastases.

Metastatic Site–Specific Outcomes With 1L ccRCC Therapies

Panelists discuss how clinical decision-making with TKI-IO combinations for advanced renal cell carcinoma involves evaluating factors such as efficacy, safety, patient characteristics, and the management of treatment-related toxicities to optimize patient outcomes.

Clinical Decision-making With TKI-IO Combinations for Advanced RCC

Panelists discuss how the Phase phase 3 CLEAR trial evaluates organ-specific progression patterns in advanced renal cell carcinoma to better understand the efficacy of lenvatinib plus pembrolizumab compared to with sunitinib and guide subsequent treatment strategies.

Phase 3 CLEAR Trial: Evaluating Organ-Specific Progression Patterns

Panelists discuss the multidisciplinary team’'s role in supporting patients through a renal cell carcinoma n( RCC) diagnosis, addressing informational gaps as patients process their diagnosis, offering supportive strategies and resources, and highlighting the unique challenges faced by patients with clear cell RCC compared to with those with non–-clear cell RCC.

The Role of the Multidisciplinary Care Team in RCC

Panelists discuss the broader treatment landscape for advanced clear cell renal cell carcinoma (RCC), outlining the current standards of care, how treatment approaches vary for aggressive versus benign or indolent tumors, and the approach to shared decision-making with patients, including counseling and educating them on different treatment options.

Exploring Standards of Care and Treatment Goals in Advanced Clear Cell RCC

Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

Clinical Decision-making With TKI-IO Combinations for Advanced RCC

EP: 1.1L Treatment Landscape for Advanced Renal Cell Carcinoma

EP: 2.Metastatic Site–Specific Outcomes With 1L ccRCC Therapies

EP: 3.Clinical Decision-making With TKI-IO Combinations for Advanced RCC

EP: 4.Phase 3 CLEAR Trial: Evaluating Organ-Specific Progression Patterns

EP: 5.The Role of the Multidisciplinary Care Team in RCC

EP: 6.Exploring Standards of Care and Treatment Goals in Advanced Clear Cell RCC