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FACE-OFF: Team Blue vs Team Purple

Video Series

Do We Start Luspatercept at the Highest Dose and Titrate Down or Start Low and Titrate Up?

Videos

Amer Zeidan, MBBS; Catherine Lai, MD; Bart Scott, MD; Andrew Brunner, MD; Jonathan Abbas, MD; Akriti Jain, MD; Mohamed Hegazi, MD; Somedeb Ball, MBBS; and Salman Fazal, MD, examine critical clinical decisions in myelodysplastic syndrome management, including optimal sequencing of erythropoiesis-stimulating agents vs luspatercept, dosing strategies, and efficacy data from pivotal trials such as MEDALIST, IMerge, and ELEMENT-MDS, which demonstrate improvements in transfusion burden and hemoglobin levels.

Panelists discuss how long-term analysis of the ELEMENTS trial reveals significant improvements in red blood cell (RBC) transfusion burden and hemoglobin levels among study participants.

COMMANDS: Long-Term Analysis, Changes in RBC Transfusion Burden, Hemoglobin Levels and ELEMENTS Trial

Panelists discuss how the MEDALIST and IMerge trials provide crucial insights into novel therapeutic approaches for treating myelodysplastic syndromes.

MEDALIST and IMerge Trial Presentation and Discussion

Panelists discuss how clinicians should weigh the decision between initiating treatment with erythropoiesis-stimulating agents (ESAs) vs luspatercept in patients with myelodysplastic syndromes.

Debate: Do We Treat First With ESAs or With Luspatercept? 

Panelists discuss how to optimize luspatercept dosing strategies by evaluating the benefits and risks of starting at maximum dose with downward titration vs initiating at lower doses with upward adjustments.

Panelists discuss how to approach patients who show inadequate response to initial erythropoiesis-stimulating agent (ESA) therapy, including assessment strategies and potential next steps in treatment modification.

Clinical Scenario: Patient Receiving First-Line ESA Without a Marked Response: What Do You Do Next?

Panelists discuss how to develop treatment strategies for patients with ring sideroblasts and genetic abnormalities, focusing on the role of specialized therapies and the importance of molecular testing in guiding clinical decisions.

Clinical Scenario: How Do We Treat Patients With Ring Sideroblast/Genetic Abnormalities?

CancerNetwork® Face-Off

is a live event hosted by CancerNetwork® in which renowned cancer institutions go head-to-head in a friendly debate on the latest data in a specific therapeutic area. The Face-Off program provides the ideal platform for a meaningful dialogue and data review among fellows and attending junior oncologists, as well as other key stakeholders.

Do We Start Luspatercept at the Highest Dose and Titrate Down or Start Low and Titrate Up?

EP: 1.COMMANDS: Long-Term Analysis, Changes in RBC Transfusion Burden, Hemoglobin Levels and ELEMENTS Trial

EP: 2.MEDALIST and IMerge Trial Presentation and Discussion

EP: 3.Debate: Do We Treat First With ESAs or With Luspatercept?

EP: 4.Do We Start Luspatercept at the Highest Dose and Titrate Down or Start Low and Titrate Up?

EP: 5.Clinical Scenario: Patient Receiving First-Line ESA Without a Marked Response: What Do You Do Next?

EP: 6.Clinical Scenario: How Do We Treat Patients With Ring Sideroblast/Genetic Abnormalities?