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Optimizing Outcomes in Patients with HER2+ Metastatic Breast Cancer

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PALOMA-3: Subcutaneous Amivantamab + Lazertinib for EGFR+ NSCLC

Video Series

PALOMA-3: Key End Points: Pharmacokinetic and Secondary

Videos

Joshua K. Sabari, MD, and Martin Dietrich, MD, PhD, examine both the evolution of first-line EGFR TKIs as standard treatment for EGFR-mutated metastatic non-small cell lung cancer and the ongoing clinical challenges in managing resistance, toxicities, and treatment sequencing in this space.

A panelist discusses how targeted therapies such as EGFR tyrosine kinase inhibitors have become the standard first-line treatment for patients with EGFR-mutated metastatic non–small cell lung cancer, offering improved outcomes compared with traditional chemotherapy.

EGFR mNSCLC Front-Line: Treatment Options

A panelist discusses how managing resistance mechanisms and toxicity profiles and identifying optimal sequencing strategies remain key challenges in treating EGFR-mutated metastatic non–small cell lung cancer despite advances in targeted therapies.

EGFR mNSCLC: Challenges with Treatments in this Space

Panelists discuss how managing adverse events and selecting optimal treatment strategies remain key challenges in front-line EGFR-mutated, non–small cell lung cancer (mNSCLC) therapy, particularly when weighing the efficacy and toxicity profiles of available targeted therapies.

EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

Panelists discuss how PALOMA-3, a phase 3 randomized clinical trial, was designed to evaluate palbociclib plus fulvestrant vs placebo plus fulvestrant in patients with hormone receptor–positive, HER2-negative advanced breast cancer who had progressed on prior endocrine therapy.

PALOMA-3: Study Design and Baseline Characteristics

Panelists discuss how PALOMA-3’s pharmacokinetic and secondary end point analyses demonstrated the clinical benefit of palbociclib through multiple measures, including progression-free survival, objective response rate, and drug concentration levels that inform optimal dosing strategies.

Panelists discuss how the safety profile of palbociclib plus fulvestrant in PALOMA-3 was characterized by manageable adverse events, with neutropenia being the most common but rarely leading to treatment discontinuation.

PALOMA-3: Key Safety Data

Between The Lines

 is an engaging 30- to 45-minute open discussion showcasing insightful and impactful perspectives from academic and community oncologists on published, peer-reviewed content.

PALOMA-3: Key End Points: Pharmacokinetic and Secondary

EP: 1.EGFR mNSCLC Front-Line: Treatment Options

EP: 2.EGFR mNSCLC: Challenges with Treatments in this Space

EP: 3.EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

EP: 4.PALOMA-3: Study Design and Baseline Characteristics

EP: 5.PALOMA-3: Key End Points: Pharmacokinetic and Secondary

EP: 6.PALOMA-3: Key Safety Data