Fred Hutchinson center to collaborate with Chinese agency on cancer research (and more)
November 9th 2010The Fred Hutchinson Cancer Research Center has signed a formal agreement with China's version of the CDC. One goal is to carry out research on large datasets, with the aim of finding new cancer biomarkers.
FDA and Avastin: Crossroads in an Era of Targeted Therapies
October 25th 2010In early 2008, based on the results of its E2100 trial, which showed significant improvements in progression-free survival when combined with paclitaxel, Avastin (bevacizumab) gained an FDA accelerated approval. Median progression-free survival in the Avastin arm was 11.3 months compared with 5.8 months for paclitaxel alone (although overall survival in the two arms was similar). However, final approval would be dependent on subsequent trials showing similar degrees of benefit. When two additional trials were submitted for review, both showed significant improvements in progression-free survival, but again with no difference in overall survival. Subsequently, on July 20th of this year, the Oncologic Drugs Advisory Committee (ODAC) voted 12 to 1 not to recommend permanent approval of Avastin as first-line therapy in advanced breast cancer.
Zinecard offers cardioprotection
October 20th 2010Children undergoing anthracycline therapy for acute lymphoblastic leukemia saw cardioprotective benefits with dexrazoxane (Zinecard or Cardioxane), which signifi cantly reduced the occurrence of long-term heart damage without negatively aff ecting the eff ectiveness of chemotherapy.
Childhood cancer haunts survivors in unexpected ways
October 20th 2010Radiation doses to the heart of about 5 Gy or greater in childhood are associated with long-term cardiovascular consequences, including early mortality. Cancer care specialists strive to balance late-stage effects without sacrificing treatment benefits.
Common cancer link may unleash potential of antibodies and antiangiogenesis
October 19th 2010The search for a magic bullet against cancer historically has glowed bright then dimmed, depending on the stage of discovery. Developments surrounding monoclonal antibodies and angiogenesis inhibitors have followed this cycle, as exuberance for their potential has bowed to the nuances that underlie the complex mechanisms on which they depend.