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Optimizing Treatment Strategies for Advanced Upper GI Cancers

Video Series

Megan’s Journey With HER2+ Upper GI Cancer

Video content above is prompted by the following:

Videos

Experts discuss treatment strategies for advanced upper gastric cancers, focusing on biomarker testing, treatment options, and managing adverse effects.

Experts discuss Robert’s journey with HER2-positive upper gastrointestinal (GI) cancer, highlighting key treatment approaches and challenges.

Robert’s Journey With HER2  Upper GI Cancer

Experts discuss frontline treatment options for advanced upper gastric adenocarcinoma, molecular testing methods, challenges encountered, and how test results influence the choice of systemic therapy for patients.

Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

Experts discuss the role of reflex testing in ensuring accurate and timely treatment selection, the challenges it may present, and how it can be integrated with next-generation sequencing (NGS) to provide a comprehensive molecular profile while minimizing delays.

Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

Experts discuss the relevance of PD-L1 CPS in predicting immunotherapy efficacy, other complementary biomarkers, the benefits of adding nivolumab to a FOLFOX regimen, and how the CheckMate 649 trial and its recent 5-year update have influenced the use of nivolumab in combination with chemotherapy for advanced gastric and gastroesophageal adenocarcinomas.

The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

Experts discuss how biomarker testing results should be reassessed or expanded upon disease progression and how they guide the selection of second-line therapies or clinical trial enrollment.

Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

Experts discuss how to approach prognosis and treatment goals with a patient, considering their family history of gastric cancer and advanced-stage disease.

Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

Experts discuss Megan’s journey with HER2-positive upper gastrointestinal (GI) cancer, highlighting key treatment strategies and challenges.

Experts discuss the PD-L1 combined positive score (CPS) and its influence on treatment decisions as well as the clinical significance of a high CPS in guiding the use of immune checkpoint inhibitors such as pembrolizumab in HER2-positive gastric cancer.

Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer

Megan’s Journey With HER2+ Upper GI Cancer

EP: 1.Robert’s Journey With HER2 Upper GI Cancer

EP: 2.Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

EP: 3.Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

EP: 4.The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

EP: 5.Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

EP: 6.Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

EP: 7.Megan’s Journey With HER2+ Upper GI Cancer

EP: 8.Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer