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Opinion|Videos|March 7, 2025

The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

Author(s)David Zhen, MD, Nataliya V. Uboha, MD, PhD, Samuel Cytryn, MD

Experts discuss the relevance of PD-L1 CPS in predicting immunotherapy efficacy, other complementary biomarkers, the benefits of adding nivolumab to a FOLFOX regimen, and how the CheckMate 649 trial and its recent 5-year update have influenced the use of nivolumab in combination with chemotherapy for advanced gastric and gastroesophageal adenocarcinomas.

Episodes in this series

EP. 1 HER2- Upper GI Cancer

EP. 1 HER2- Upper GI Cancer

EP. 2 Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

EP. 2 Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

EP. 3 Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

EP. 3 Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

EP. 4 The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

EP. 4 The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

EP. 5 Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

EP. 5 Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

EP. 6 Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

EP. 6 Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 8 Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer

EP. 8 Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer

EP. 9 ADCs in HER2+ Gastric Cancer

EP. 9 ADCs in HER2+ Gastric Cancer

EP. 10 Biomarkers and Clinical Features Guiding HER2-Directed Therapy in Upper GI Cancer

EP. 10 Biomarkers and Clinical Features Guiding HER2-Directed Therapy in Upper GI Cancer

EP. 11 Considerations for Combinations Beyond Progression in Upper GI Cancer

EP. 11 Considerations for Combinations Beyond Progression in Upper GI Cancer

EP. 12 Exploring Next-Line Options in HER2- MSS Gastric Cancer

EP. 12 Exploring Next-Line Options in HER2- MSS Gastric Cancer

Video content above is prompted by the following:

• How relevant is PD-L1 CPS in predicting the efficacy of immunotherapy in this context, and are there other biomarkers that could complement CPS in selecting patients for IO therapies?
• What is the benefit of adding nivolumab to a FOLFOX regimen in this patient, and how does immunotherapy enhance the efficacy of chemotherapy in this setting?
• How has the CheckMate 649 trial influenced the use of nivolumab in combination with chemotherapy for advanced gastric and gastroesophageal adenocarcinomas?
• Please comment on the recently presented 5-year update of CheckMate 649

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